PREVENTING ASTHMA EPIDEMICS DUE TO SOYBEANS BY DUST-CONTROL MEASURES
PREVENTING ASTHMA EPIDEMICS DUE TO SOYBEANS BY DUST-CONTROL MEASURES
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DOI：
10.1056/nejm199312093292402
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发表时间：
1993-12-09
影响因子：
158.5
通讯作者：
SAEZ, M
中科院分区：
文献类型：
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作者：
ANTO, JM;SUNYER, J;SAEZ, M
背景。西班牙巴塞罗那爆发哮喘病，原因是吸入将大豆卸入筒仓时释放的大豆粉尘。本研究旨在确定筒仓中安装过滤器之前和之后因哮喘和血清 IgE 反应性引起的发病率。方法。我们测量了安装过滤器之前 9 个月和安装过滤器之后 24 个月收集的 136 个空气样本中的大豆过敏原浓度。我们比较了因哮喘急诊就诊的天数意外增加的天数、在一个四小时内因哮喘急诊就诊的人数如此之高以至于不太可能是偶然的天数，以及安装过滤器之前和之后总共 60 个月内因哮喘急诊室和重症监护病房入院的平均每日人数。在过滤器安装前后测量了 38 名患者的血清抗大豆过敏原 IgE 抗体。结果。安装过滤器后，大豆卸货日空气中大豆过敏原浓度从每立方米324U下降至25U（P）
Background. The inhalation of soybean dust released during the unloading of soybeans into a silo caused outbreaks of asthma in Barcelona, Spain. This study was designed to determine morbidity due to asthma and serum IgE reactivity before and after the installation of filters in the silo.Methods. We measured soybean-allergen concentrations in 136 samples of air collected for 9 months before and 24 months after the installation of filters. We compared the number of days on which there was an unexpected increase in emergency room visits for asthma, the number of days on which the number of emergency room visits for asthma in one four-hour period was so high that it was unlikely to be due to chance, and the mean daily number of emergency room and intensive care unit admissions for asthma for a total of 60 months before and after filter installation. Serum IgE antibodies against soybean allergens were measured in 38 patients before and after filter installation.Results. The concentration of airborne soybean allergens on days when soybeans were unloaded decreased from 324 to 25 U per cubic meter after the installation of filters (P