Telomeres and the functional architecture of the nucleus
Telomeres and the functional architecture of the nucleus
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DOI：
10.1016/0962-8924(93)90175-z
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发表时间：
1993-01-01
影响因子：
19
通讯作者：
Gasser, Susan M.
中科院分区：
文献类型：
--
作者：
Gilson, Eric;Laroche, Thierry;Gasser, Susan M.
构成真核生物染色体的DNA单分子以一段被称为端粒的重复DNA开始和结束。这些序列似乎是在细胞周期中保持遗传物质完整性所必需的。端粒DNA被组织成称为端粒的非核体染色质区域，端粒可以与其他端粒和核膜相互作用。这篇综述着重于这些相互作用的细胞学证据和最近对端粒复合体分子组织的见解。
The single molecule of DNA that constitutes a eukaryotic chromosome begins and ends with a stretch of repetitive DNA known as a telomere. These sequences appear to be necessary to preserve the integrity of the genetic material through the cell cycle.Telomeric DNA is organized into regions of non-nucleosomal chromatin called the telosome, which can interact with other telosomes and with the nuclear envelope. This review focuses on cytological evidence for these interactions and on recent insights into the molecular organization of the telomeric complex.