CENTRAL MECHANISMS OF VASCULAR HEADACHES
CENTRAL MECHANISMS OF VASCULAR HEADACHES
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DOI：
10.1139/y91-097
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发表时间：
1991-05-01
影响因子：
2.1
通讯作者：
KAWAKITA, K
中科院分区：
文献类型：
--
作者：
DOSTROVSKY, JO;DAVIS, KD;KAWAKITA, K
供应硬脑膜和大脑的颅内血管由来自三叉神经的感觉传入神经支配。 这些纤维被认为是负责传达与血管性头痛如偏头痛相关的疼痛。 本文回顾了最近发表的数据描述的存在的神经元内的猫三叉神经核和丘脑的脑膜中动脉和上级矢状窦的电刺激作出反应。 几乎所有的这些神经元都接受来自面部皮肤的会聚输入，并且大多数感受野包括眶周区域。 基于它们的皮肤输入，大多数神经元被分类为伤害性神经元。 这些脑血管激活神经元的特征与它们在介导血管性头痛中的作用一致，并且与人的这种疼痛在眼眶区域的典型转诊一致。 本文还介绍了电刺激脑膜中动脉和矢状窦激活的大鼠三叉神经节神经元记录的初步结果。 这些神经元的激活的延迟指示在缓慢传导的有髓轴突和无髓轴突中的传导。 一些神经元也可以被施加到血管的机械刺激激活。
The intracranial blood vessels supplying the dura and brain are innervated by sensory afferents from the trigeminal nerve. These fibers are believed to be responsible for conveying the pain associated with vascular head pain such as migraines. This paper reviews recently published data describing the existence of neurons within the cat trigeminal nucleus and thalamus that respond to electrical stimulation of the middle meningeal artery and superior sagittal sinus. Almost all of these neurons receive convergent input from the facial skin and most of the receptive fields include the periorbital region. On the basis of their cutaneous inputs, most of the neurons are classified as nociceptive. The characteristics of these cerebrovascular-activated neurons are consistent with their role in mediating vascular head pains and with the typical referral of such pains in man to the orbital region. This paper also presents preliminary results of recordings from rat trigeminal ganglion neurons activated by electrical stimulation of the middle meningeal artery and sagittal sinus. The latencies of activation of these neurons are indicative of conduction in slowly conducting myelinated axons and in unmyelinated axons. Some of the neurons could also be activated by mechanical stimuli applied to the vessels.