Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia.
Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia.
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DOI：
10.1586/1744666x.2015.1056780
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发表时间：
2015
影响因子：
4.4
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Smith TA;Kirkpatrick DR;Kovilam O;Agrawal DK
在世界范围内，先兆子痫对孕妇及其未出生的孩子都构成重大健康风险。尽管科学取得了进步，但先兆子痫的确切发病机制尚未完全了解。与此同时，子痫前期的发病率预计会增加。已经确定了先兆子痫的一系列潜在病因，包括内皮功能障碍、免疫失调和滋养层侵袭。在这篇文献综述中，我们批判性地回顾了有关维生素 D 的作用与先兆子痫的发病机制和免疫调节之间联系的研究结果的现有文献。维生素 D 与先兆子痫的可疑病因之间的关系强调了其在先兆子痫的诊断和治疗中的临床潜力。
Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia have been identified, including endothelial dysfunction, immunological dysregulation, and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.