A novel class (H3) of histamine receptors on perivascular nerve terminals
A novel class (H3) of histamine receptors on perivascular nerve terminals
复制标题
血管周围神经末梢上的一类新型（H3）组胺受体
DOI：
10.1038/327158a0
复制
发表时间：
1987
期刊：
影响因子：
64.8
通讯作者：
N. Sperelakis
中科院分区：
文献类型：
--
作者：
S. Ishikawa;N. Sperelakis
两种类型的组胺受体，即 H1 和 H2 受体 1,2，不仅存在于血管平滑肌细胞 3,4 上，而且存在于血管周围自主神经末梢上。结合前组胺受体的激活会改变神经末梢的递质释放5-8。最近，组胺被证明可以抑制大鼠大脑皮层去极化切片自身的释放。人们发现这种现象是由一类新型组胺受体 H3 受体介导的，该受体在药理学上与 H1 和 H2 受体不同9。到目前为止，还没有迹象表明第三类组胺受体是否存在于大脑以外的任何组织中。我们在此报告，组胺通过与血管周围神经末梢上的组胺 H3 受体相互作用，抑制豚鼠肠系膜动脉中的交感神经传递。这些受体的药理学特性与大脑中 H3 受体的药理学特性相似。我们的数据为自主神经系统中 H3 受体的存在提供了证据。
Two types of histamine receptor, the H1 and H2-receptors1,2, are found not only on vascular smooth muscle cells3,4 but on the perivascular autonomic nerve terminals. Activation of the prejunctional histamine receptors modifies transmitter release from the nerve terminals5–8. Recently, histamine was shown to inhibit its own release from depolarized slices of rat cerebral cortex. This phenomenon was found to be mediated by a novel class of histamine receptor, the H3-receptor, that was pharmacologically distinct from the H1- and H2-receptors9. Up to now, there has been no indication whether this third class of histamine receptor is present in any tissue other than the brain. We report here that histamine depresses sympathetic neurotransmission in the guinea-pig mesenteric artery by interacting with histamine H3-receptors on the perivascular nerve terminals. The pharmacological properties of these receptors are similar to those reported for the H3-receptors in the brain. Our data provide evidence for the existence of H3-receptors in the autonomic nervous system.