Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic
Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic
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DOI：
10.1097/qai.0000000000002754
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发表时间：
2021-11-01
影响因子：
3.6
通讯作者：
Ridolfo, Anna Lisa
中科院分区：
文献类型：
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作者：
Giacomelli, Andrea;Bonazzetti, Cecilia;Ridolfo, Anna Lisa
背景：我们评估了2019冠状病毒病（COVID-19）大流行对在意大利一家大型艾滋病毒诊所就诊的艾滋病毒感染者（PLWH）的艾滋病毒抑制率的影响。地点：意大利米兰路易吉萨科医院传染病科艾滋病门诊，每年为5000多名艾滋病患者提供服务。方法：采用准实验设计，以2016年1月1日至2020年2月20日为就诊前，以2020年2月21日至2020年12月31日（新冠疫情期间）为就诊后，回顾性评估就诊前PLWH患者>= 50 HIV-RNA检测的月度趋势。使用中断时间序列分析来评估趋势的变化。结果：研究期间共检测HIV-RNA病毒载量70,349次，大流行前HIV-RNA病毒载量检测百分比= 50 copies/mL (beta -0.084，标准误差0.015,P < 0.001)，大流行开始后无显著变化（beta -0.039，标准误差0.161,P = 0.811）。结论：尽管COVID-19大流行带来了结构性障碍，但在我们诊所就诊的PLWH中，病毒抑制的流行率仍然很高。使用简化的提供护理方法（如远程会诊和多种抗逆转录病毒治疗处方）可能有助于保持这一连续性。
Background: We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HIV suppression rates in people living with HIV (PLWH) attending a large Italian HIV clinic. Setting: The HIV outpatient clinic of the Infectious Diseases Department of Luigi Sacco Hospital, Milan, Italy, which serves more than 5000 PLWH per year. Methods: A before and after quasi-experimental study design was used to make a retrospective assessment of the monthly trend of HIV-RNA determinations of >= 50 among the PLWH attending our clinic, with "before" being the period from January 1, 2016 to February 20, 2020, and "after" being the period from February 21, 2020 to December 31, 2020 (the COVID-19 period). Interrupted time series analysis was used to evaluate any changes in the trend. Results: During the study period, 70,349 HIV-RNA viral load determinations were made, and the percentage of HIV-RNA viral load determinations of = 50 copies/mL before the pandemic (beta -0.084; standard error 0.015; P < 0.001), and this did not significantly change after it started (beta -0.039, standard error 0.161; P = 0.811). Conclusions: A high prevalence of viral suppression was maintained among the PLWH referring to our clinic, despite the structural barriers raised by the COVID-19 pandemic. The use of simplified methods of delivering care (such as teleconsultations and multiple antiretroviral treatment prescriptions) may have contributed to preserving this continuum.