Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children.
Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children.
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DOI：
10.1002/jmri.24888
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Sirlin CB
中科院分区：
文献类型：
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作者：
Zand KA;Shah A;Heba E;Wolfson T;Hamilton G;Lam J;Chen J;Hooker JC;Gamst AC;Middleton MS;Schwimmer JB;Sirlin CB
以磁共振波谱（MRS）测量的肝脏质子密度脂肪分数（PDFF）作为参考标准，评估基于幅度的磁共振成像（M-MRI）在儿童中使用2至6个回波估计肝脏质子密度脂肪分数（PDFF）的准确性。这是一项IRB批准的、符合HIPAA的、单中心、横断面、回顾性分析，对2008年至2013年期间在已知或疑似非酒精性脂肪肝（NAFLD）儿童中前瞻性收集的数据进行分析。286名儿童（8 - 20 [平均14.2 ± 2.5]岁; 182名男孩）在同一天接受了MRS和M-MRI。单次低翻转角（10°）激发后，在3 T下获得6个回波时间的未增强二维轴向扰相梯度回波图像，恢复时间≥ 120 ms。使用前两个、三个、四个、五个和所有六个回波估计肝脏PDFF。对于每个回波数，以MRS-PDFF为参考标准，通过线性回归评估M-MRI估计PDFF的准确性。准确度指标为回归截距、斜率、平均偏倚和R2。MRS-PDFF范围为0.2 - 40.4%（平均13.1 ± 9.8%）。使用3 - 6个回波，回归截距、斜率和平均偏倚分别为0.46 - 0.96%、0.99 - 1.01和0.57 - 0.89%。使用两个回波，这些值分别为2.98%、0.97和2.72%。所有方法的R2范围为0.98 - 0.99。使用3至6个回波，M-MRI对儿童肝脏PDFF估计具有较高的准确性。
To assess accuracy of magnitude-based magnetic resonance imaging (M-MRI) in children to estimate hepatic proton density fat fraction (PDFF) using two to six echoes, with magnetic resonance spectroscopy (MRS)-measured PDFF as a reference standard. This was an IRB-approved, HIPAA-compliant, single-center, cross-sectional, retrospective analysis of data collected prospectively between 2008 and 2013 in children with known or suspected non-alcoholic fatty liver disease (NAFLD). Two hundred and eighty-six children (8 – 20 [mean 14.2 ± 2.5] yrs; 182 boys) underwent same-day MRS and M-MRI. Unenhanced two-dimensional axial spoiled gradient-recalled-echo images at six echo times were obtained at 3T after a single low-flip-angle (10°) excitation with ≥ 120-ms recovery time. Hepatic PDFF was estimated using the first two, three, four, five, and all six echoes. For each number of echoes, accuracy of M-MRI to estimate PDFF was assessed by linear regression with MRS-PDFF as reference standard. Accuracy metrics were regression intercept, slope, average bias, and R2. MRS-PDFF ranged from 0.2 – 40.4% (mean 13.1 ± 9.8%). Using three to six echoes, regression intercept, slope, and average bias were 0.46 – 0.96%, 0.99 – 1.01, and 0.57 – 0.89%, respectively. Using two echoes, these values were 2.98%, 0.97, and 2.72%, respectively. R2 ranged 0.98 – 0.99 for all methods. Using three to six echoes, M-MRI has high accuracy for hepatic PDFF estimation in children.