Risk factors for neonatal group B streptococcus vertical transmission: a prospective cohort study of 1815 mother-baby pairs
Risk factors for neonatal group B streptococcus vertical transmission: a prospective cohort study of 1815 mother-baby pairs
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新生儿 B 族链球菌垂直传播的危险因素：1815 对母婴的前瞻性队列研究
DOI：
10.1038/s41372-018-0182-z
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发表时间：
2018-10-01
影响因子：
2.9
通讯作者：
Ye, Xiaohua
中科院分区：
文献类型：
--
作者：
Chen, Zhiyao;Wu, Chuan'an;Ye, Xiaohua
背景与B族链球菌（GBS）垂直传播相关的潜在因素尚未被详细研究。研究设计一项前瞻性队列研究招募了1815对母婴对进行GBS分析。结果新生儿GBS垂直传播率为14.1%，新生儿GBS垂直传播率为14.1%。所有新生儿的GBS定植与母体GBS定植、分娩方式、会阴切开术、产前阴道检查次数、产次和高血压显著相关。对于GBS阳性母亲所生的新生儿，GBS垂直传播与分娩方式、会阴切开术和性传播疾病有关。对于GBS阴性母亲所生的新生儿，新生儿GBS定植与产前阴道检查，产次，和hypertension.Conclusion这些研究结果表明，需要产前GBS筛查孕妇和产时抗生素预防GBS定植的妇女。
Background The potential factors associated with group B streptococcus (GBS) vertical transmission have not been studied in detail.Study design A prospective cohort study was conducted to recruit 1815 mother-neonate pairs for GBS analysis. Pearson's chi-squared tests and generalized linear models were used to explore the risk factors for neonatal GBS colonization.Results The rate of GBS vertical transmission was 14.1%. GBS colonization in all neonates was significantly associated with maternal GBS colonization, mode of delivery, episiotomy, number of prenatal vaginal exams, parity, and hypertension. For neonates born to GBS-positive mothers, GBS vertical transmission was associated with the mode of delivery, episiotomy, and sexually transmitted diseases. For neonates born to GBS-negative mothers, neonatal GBS colonization was associated with the number of prenatal vaginal exams, parity, and hypertension.Conclusion These findings suggest the need for prenatal GBS screening for pregnant women and intrapartum antimicrobial prophylaxis for GBS-colonized women.