Sequential mono-N-arylation of piperazine nitrogens.: Part 2:: The role of hydrogen bonding
Sequential mono-N-arylation of piperazine nitrogens.: Part 2:: The role of hydrogen bonding
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DOI：
10.1016/s0040-4039(99)01104-1
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发表时间：
1999-07-30
影响因子：
1.8
通讯作者：
Gala, D
中科院分区：
文献类型：
--
作者：
Eckert, J;Chan, TM;Gala, D
哌嗪简单连续N-芳基化反应的机理研究表明，在含吸电子基团的N-芳基化哌嗪中，仲胺氢的氢键对于其非金属催化转化为N，N '-二芳基哌嗪是重要的。合成实验，分子建模和NMR研究的组合进行了测试这一假设。(C)1999 Elsevier Science Ltd.保留所有权利。
A mechanistic study of the simple sequential N-arylation of piperazine suggests that in an electron-withdrawing group (EWG) containing N-arylated piperazines, hydrogen bonding of the secondary amine hydrogen is important for its non-metal catalyzed conversion to N,N'-diaryl piperazines. A combination of synthetic experiments, molecular modeling, and NMR studies were carried out to test this hypothesis. (C) 1999 Elsevier Science Ltd. All rights reserved.