Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth
Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth
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DOI：
10.1002/jbm.b.10485
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发表时间：
2003-02-15
影响因子：
3.4
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Cooke, MN;Fisher, JP;Mikos, AG
提出了一种利用光固化快速成型技术（SLA）制备可生物降解组织工程支架的新方法。SLA是一种三维（3D）打印方法，其使用紫外激光来光交联液体聚合物基底。当前一代SLA设备提供0.1 mm的3D打印分辨率。实验使用了富马酸二乙酯（DEF）、聚富马酸丙二醇酯（PPF）和光引发剂双酰基氧化膦（BAPO）的生物可降解树脂混合物。使用SLA的UV激光（325 nm波长）交联PPF。SLA设备被改造为具有定制夹具构建罐，该定制夹具构建罐封闭升降机驱动的构建台。在计算机辅助设计包中创建了一个3D原型模型，用于测试该设备提供的制造控制。生成的几何数据用于驱动SLA过程，并成功制造了DEF/PPF原型零件。这些支架在骨基质的组织工程中具有应用。(C)2002 Wiley Periodicals，Inc.
A novel approach to the manufacture of biodegradable polymeric scaffolds for tissue-engineering utilizing stereolithography (SLA) is presented. SLA is a three-dimensional (3D) printing method that uses an ultraviolet laser to photo-crosslink a liquid polymer substrate. The current generation of SLA devices provide a 3D printing resolution of 0.1 mm. The experiments utilized a biodegradable resin mixture of diethyl fumarate (DEF), poly(propylene fumarate) (PPF), and a photoinitiator, bisacylphosphine oxide (BAPO). The PPF is crosslinked with the use of the SLA's UV laser (325-nm wavelength). An SLA device was retrofitted with a custom fixture build tank enclosing an elevator-driven build table. A 3D prototype model testing the manufacturing control this device provides was created in a computer-aided-design package. The resulting geometric data were used to drive the SLA process, and a DEF/PPF prototype part was successfully manufactured. These scaffolds have application in the tissue engineering of bony substrates. (C) 2002 Wiley Periodicals, Inc.