Mixed-mode pattern in Doublefoot mutant mouse limb -: Turing reaction-diffusion model on a growing domain during limb development
Mixed-mode pattern in Doublefoot mutant mouse limb -: Turing reaction-diffusion model on a growing domain during limb development
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DOI：
10.1016/j.jtbi.2005.10.016
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发表时间：
2006-06-21
影响因子：
2
通讯作者：
Maini, Philip K.
中科院分区：
文献类型：
--
作者：
Miura, Takashi;Shiota, Kohei;Maini, Philip K.
有人建议，图灵反应扩散模型的增长域是适用于肢体发育，但这一假设的实验证据一直缺乏。在本研究中，我们发现，在双足突变小鼠，这有多余的手指，由于过度扩张的肢芽，薄的手指存在于近端部分的手或脚，有时突然变成正常的远端部分。我们发现，完全相同的行为可以复制的最简单的图灵反应扩散模型的数值模拟上的增长域。我们分析表明，这种模式是有关的饱和活化剂动力学模型。此外，我们表明，在这个系统中的实验观察到的现象可以解释的图灵反应扩散模型的背景下。最后，我们做了一些实验验证的预测。(c)2005爱思唯尔有限公司保留所有权利。
It has been suggested that the Turing reaction-diffusion model on a growing domain is applicable during limb development, but experimental evidence for this hypothesis has been lacking. In the present study, we found that in Doublefoot mutant mice, which have supernumerary digits due to overexpansion of the limb bud, thin digits exist in the proximal part of the hand or foot, which sometimes become normal abruptly at the distal part. We found that exactly the same behaviour can be reproduced by numerical simulation of the simplest possible Turing reaction-diffusion model on a growing domain. We analytically showed that this pattern is related to the saturation of activator kinetics in the model. Furthermore, we showed that a number of experimentally observed phenomena in this system can be explained within the context of a Turing reaction-diffusion model. Finally, we make some experimentally testable predictions. (c) 2005 Elsevier Ltd. All rights reserved.