What types of contacts are important for the spread of infections? Using contact survey data to explore European mixing patterns
What types of contacts are important for the spread of infections? Using contact survey data to explore European mixing patterns
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DOI：
10.1016/j.epidem.2011.04.001
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发表时间：
2011-09-01
期刊：
影响因子：
3.8
通讯作者：
Edmunds, W. John
中科院分区：
文献类型：
--
作者：
Melegaro, Alessia;Jit, Mark;Edmunds, W. John
了解传染病传播的决定因素是公共卫生的首要任务，因为它可以为地方性或新发感染设计最佳控制策略。我们分析了五个欧洲国家接触模式的详细数据集，并使用水痘和细小病毒 B19 感染的可用血清学特征来确定可能与传播最相关的接触类型。我们表明，由接触数据提供的模型与观察到的两种感染的血清学特征非常吻合。我们发现，亲密类型的接触比其他类型的社会接触更好地解释了按年龄获得血清学标记的模式。我们在每个分析的国家中观察到类似的模式，这表明存在一致的生物机制在起作用。 (C) 2011 Elsevier B.V. 保留所有权利。
Knowledge of the determinants of infectious disease transmission is a public health priority as it allows the design of optimal control strategies for endemic or emerging infections. We analyse a detailed dataset on contact patterns across five European countries and use available serological profiles for varicella and parvovirus B19 infections to identify the types of contact that may be most relevant for transmission. We show that models informed by contact data fit well the observed serological profiles of both infections. We find that intimate types of contacts explain the pattern of acquisition of serological markers by age better than other types of social contacts. We observe similar patterns in each of the countries analysed, suggesting that there are consistent biological mechanisms at work. (C) 2011 Elsevier B. V. All rights reserved.