Phylogenetic lineages of invasive and colonizing strains of serotype III group B streptococci from neonates: A multicenter prospective study
Phylogenetic lineages of invasive and colonizing strains of serotype III group B streptococci from neonates: A multicenter prospective study
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DOI：
10.1128/jcm.44.4.1257-1261.2006
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发表时间：
2006-04-01
影响因子：
9.4
通讯作者：
Bohnsack, JF
中科院分区：
文献类型：
--
作者：
Lin, FYC;Whiting, A;Bohnsack, JF
本研究比较了侵袭性血清型III组B链球菌（GBS）的系统发育谱系，以确定与侵袭性疾病相关的谱系。在一项前瞻性、多中心研究中收集了29例早发性疾病（EOD）婴儿和196例定植婴儿的分离株，通过多位点序列分型将其分配给一个序列型（ST）。总体而言，54.5%的分离株在ST-19复合群中，40.4%在ST-17复合群中。ST-17复合体中的侵袭性菌株比定殖菌株更有可能存在（59%对38%，P = 0.03）。在我们调整了潜在的混杂因素后，ST-17复合体比其他谱系更可能与EOD相关（比值比= 2.51，95%置信区间= 1.02至6.20）。这些数据支持ST-17复合物GBS比其他血清型III GBS更毒力的假设。
This study compares the phylogenetic lineages of invasive serotype III group B streptococci (GBS) to those of colonizing strains in order to determine lineages associated with invasive disease. Isolates from 29 infants with early-onset disease (EOD) and from 196 colonized infants, collected in a prospective, multicenter study, were assigned a sequence type (ST) by multilocus sequence typing. Overall, 54.5% of the isolates were in the ST-19 complex, and 40.4% were in the ST-17 complex. Invasive strains were more likely to be in the ST-17 complex than were colonizing strains (59% versus 38%, P = 0.03). After we adjusted for potential confounders, the ST-17 complex was more likely to be associated with EOD than were other lineages (odds ratio = 2.51, 95% confidence interval = 1.02 to 6.20). These data support the hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS.