Apoptosis in Cellular Society: Communication between Apoptotic Cells and Their Neighbors.
Apoptosis in Cellular Society: Communication between Apoptotic Cells and Their Neighbors.
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DOI：
10.3390/ijms17122144
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发表时间：
2016-12-20
影响因子：
5.6
通讯作者：
Kuranaga E
中科院分区：
文献类型：
--
作者：
Kawamoto Y;Nakajima YI;Kuranaga E
细胞凋亡是一种细胞内在的自杀程序，是动物生长发育和内环境稳定的重要细胞行为。传统上，细胞凋亡被认为是一种细胞自主现象。然而，最近的体内遗传学研究表明，凋亡细胞积极影响周围细胞的行为，包括吞噬，增殖和机械力的产生。这种相互作用可以是双向的，并且细胞凋亡在细胞群落中是非自主诱导的。值得注意的是，越来越明显的是，凋亡细胞和活细胞之间的积极沟通有助于组织重塑，再生和形态发生过程中的生理过程。本文就细胞社会中凋亡细胞与其邻近细胞之间的相互作用进行综述，并对未来凋亡研究的相关问题进行讨论。
Apoptosis is one of the cell-intrinsic suicide programs and is an essential cellular behavior for animal development and homeostasis. Traditionally, apoptosis has been regarded as a cell-autonomous phenomenon. However, recent in vivo genetic studies have revealed that apoptotic cells actively influence the behaviors of surrounding cells, including engulfment, proliferation, and production of mechanical forces. Such interactions can be bidirectional, and apoptosis is non-autonomously induced in a cellular community. Of note, it is becoming evident that active communication between apoptotic cells and living cells contributes to physiological processes during tissue remodeling, regeneration, and morphogenesis. In this review, we focus on the mutual interactions between apoptotic cells and their neighbors in cellular society and discuss issues relevant to future studies of apoptosis.
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影响因子：
4.5
作者：
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作者：
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通讯作者：
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影响因子：
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影响因子：
64.8
作者：
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