pH-Responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release
pH-Responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release
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DOI：
10.1021/bm2006483
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发表时间：
2011-08-01
影响因子：
6.2
通讯作者：
Tsitsilianis, Constantinos
中科院分区：
文献类型：
--
作者：
Popescu, Maria-Teodora;Mourtas, Spyridon;Tsitsilianis, Constantinos
探索了一种新型的脂质体/水凝胶软纳米复合物作为药物控释系统。使用P2 VP-PAA-PnBMA生物相容性、pH响应性三嵌段凝胶剂作为可注射胶凝剂，包埋装载有钙黄绿素的PC/Chol脂质体作为亲水性模型药物。复合水凝胶在体外形成的pH诱导的溶胶-凝胶转变，通过透析对缓冲液在生理条件下，在聚合物浓度低至1重量%。仅通过调节胶凝剂浓度就实现了对钙黄绿素释放的优异控制;即，从1重量%至1.5重量%，药物释放期从14天显著延长至32天。
A novel liposome/hydrogel soft nanocomposite was explored as a controlled drug delivery system. A P2VP-PAA-PnBMA biocompatible, pH-responsive triblock terpolymer was used as an injectable gelator, entrapping PC/Chol liposomes loaded with calcein as hydrophilic model drug. The composite hydrogel was formed in vitro through a pH-induced sol-gel transition by dialysis against buffer under physiological conditions and at polymer concentration as low as 1 wt %. Excellent control of the calcein release was achieved just by adjusting the gelator concentration; that is, from 1 to 1.5 wt %, the drug release period was significantly prolonged from 14 to 32 days.