Characteristics of very poor outcome schizophrenia.
Characteristics of very poor outcome schizophrenia.
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预后极差的精神分裂症的特征。
DOI：
10.1176/ajp.144.7.889
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Davis,KL
中科院分区：
文献类型：
--
作者：
Keefe,RS;Mohs,RC;Losonczy,MF;Davidson,M;Silverman,JM;Kendler,KS;Horvath,TB;Nora,R;Davis,KL
作者将21名在过去5年中患病并依赖他人的“克拉佩林”精神分裂症患者与76名缓解期或需要住院治疗的慢性精神分裂症患者进行了比较。与病情加重的患者相比，Kraepelian患者在更多的诊断系统上符合精神分裂症的标准，对氟哌啶醇的反应较差，有更严重的阴性症状，并有类似严重的阳性症状。与其他慢性患者相比，他们的脑室更加不对称，精神分裂症谱系障碍的家族史更多。这些数据表明，患病5年并完全依赖他人的患者可能代表着精神分裂症的一个亚群。
The authors compared 21" Kraepelinian" schizophrenic patients who had been ill and dependent on others for the past 5 years with 76 chronic schizophrenic patients in remission or with exacerbations requiring hospitalization. The Kraepelinian patients met the criteria for schizophrenia by more diagnostic systems than the exacerbated patients, were less responsive to haloperidol, had more severe negative symptoms, and had similarly severe positive symptoms. They had cerebral ventricles that were more asymmetrical and a greater family history of schizophrenia spectrum disorders than the other chronic patients. These data suggest that patients with 5 years of illness and complete dependency on others may represent a subgroup of schizophrenia.