Formation of COPI-coated vesicles at a glance
Formation of COPI-coated vesicles at a glance
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DOI：
10.1242/jcs.209890
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发表时间：
2018-03-01
影响因子：
4
通讯作者：
Schwappach, Blanche
中科院分区：
文献类型：
--
作者：
Arakel, Eric C.;Schwappach, Blanche
外壳蛋白复合物I（COPI）允许高尔基体池之间的脂质和蛋白质的精确分选以及从高尔基体到ER的检索。这种重要作用维持早期分泌途径的特性，并影响关键的细胞过程，如蛋白质质量控制。在这篇细胞科学一瞥和附带的海报中，我们说明了COPI包被囊泡形成的不同阶段，并在阐明COPI外壳结构的最新进展的背景下回顾了几十年的研究。通过提请注意一系列尚未解决的问题，这一审查试图重新关注该领域的观点。
The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular processes, such as protein quality control. In this Cell Science at a Glance and accompanying poster, we illustrate the different stages of COPI-coated vesicle formation and revisit decades of research in the context of recent advances in the elucidation of COPI coat structure. By calling attention to an array of questions that have remained unresolved, this review attempts to refocus the perspectives of the field.