Endotoxin exposure in utero increases ethanol consumption in adult male offspring.
Endotoxin exposure in utero increases ethanol consumption in adult male offspring.
复制标题
子宫内的内毒素暴露会增加成年男性后代的乙醇消耗。
DOI：
10.1097/00001756-200401190-00039
复制
发表时间：
2004
期刊：
影响因子：
1.7
通讯作者：
Pechnick,RobertN
中科院分区：
文献类型：
--
作者：
Liu,Xiu;Lee,JamesG;Yee,SusanK;Bresee,CatherineJ;Poland,RussellE;Pechnick,RobertN
流行病学研究表明，子宫内的不良经历使个体在成年后易患神经行为障碍，包括药物滥用。本研究的目的是检查怀孕期间母体内毒素暴露会增加成年后代乙醇消耗量的假设。在整个妊娠期间，隔日对妊娠Sprague-Dawley大鼠进行脂多糖（LPS，1.0 mg/kg，sc）处理。成年雄性后代进行了测试，乙醇消耗量使用免费访问和两瓶选择范例。暴露于LPS的动物在旷场试验中表现出增加的乙醇摄入量和偏好以及降低的直立活动。这些数据表明，母亲在怀孕期间感染可能会沉淀成年后代的饮酒行为，这种影响可能是由于，至少部分是由于焦虑水平升高。
Epidemiological studies have suggested that adverse experiences in utero predispose individuals to neurobehavioral disorders including drug abuse in adulthood. The present study was designed to examine the hypothesis that maternal endotoxin exposure during pregnancy increases ethanol consumption in adult offspring. Pregnant Sprague–Dawley rats were subjected to lippopolysaccharide (LPS, 1.0 mg/kg, sc) treatment on alternate days throughout pregnancy. Adult male offspring were tested for ethanol consumption by using a free-access and two bottle choice paradigm. The animals exposed to LPS showed increased ethanol intake and preference as well as decreased rearing activity in the open field test. These data suggest that maternal infection during pregnancy might precipitate alcohol drinking behavior in adult offspring and this effect might be due, at least in part, to elevated levels of anxiety.