Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression.
Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression.
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DOI：
10.2174/1570159x16666180628165107
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发表时间：
2019
影响因子：
5.3
通讯作者：
Jiménez-Rubio G
中科院分区：
文献类型：
--
作者：
Hernández-Hernández OT;Martínez-Mota L;Herrera-Pérez JJ;Jiménez-Rubio G
在女性中，雌激素水平的变化可能会增加抑郁症的发病率和/或复发率，并影响抗抑郁治疗的反应。雌激素治疗女性可能会提供一些情绪的好处，作为一个单一的治疗或可能增加临床反应的抗抑郁药，抑制血清素再摄取。 我们分析了雌二醇作用的机制，参与调节基因表达，调节血清张力素神经传递牵连抑郁症。 通过PubMed文献检索识别出版物。 雌二醇参与抑郁症的发病机制可能包括对色氨酸羟化酶-2、单胺氧化酶A和B、5-羟色胺转运体和5-羟色胺-1A受体表达的调节。这种作用是通过雌二醇与细胞内雌激素受体结合介导的，该受体与色氨酸羟化酶-2、5-羟色胺转运蛋白和单胺氧化酶-B启动子序列中的雌激素反应元件相互作用。雌激素受体除了与脱氧核糖核酸直接结合外，还可与激活蛋白1、特异性蛋白1、CCAAT/增强子结合蛋白β和核因子κ B等转录因子结合，调控缺乏雌激素反应元件的基因启动子，如单胺氧化酶A和5-羟色胺1A受体。 雌二醇通过与其胞内受体的相互作用，增加色氨酸羟化酶-2和5-羟色胺转运体的表达，降低5-羟色胺1A受体和单胺氧化酶A和B的表达。了解雌二醇调节5-羟色胺神经传递蛋白表达的分子机制将有助于开发新的更有效的女性抑郁症治疗方法。
In women, changes in estrogen levels may increase the incidence and/or symptomatology of de-pression and affect the response to antidepressant treatments. Estrogen therapy in females may provide some mood benefits as a single treatment or might augment clinical response to antidepressants that inhibit serotonin reuptake. We analyzed the mechanisms of estradiol action involved in the regulation of gene expression that modulates sero-tonin neurotransmission implicated in depression. Publications were identified by a literature search on PubMed. The participation of estradiol in depression may include regulation of the expression of tryptophan hydroxylase-2, monoamine oxidase A and B, serotonin transporter and serotonin-1A receptor. This effect is mediated by estradiol binding to intracellular estrogen receptor that interacts with estrogen response elements in the promoter sequences of tryptophan hy-droxylase-2, serotonin transporter and monoamine oxidase-B. In addition to directly binding deoxyribonucleic acid, estrogen receptor can tether to other transcription factors, including activator protein 1, specificity protein 1, CCAAT/enhancer bind-ing protein β and nuclear factor kappa B to regulate gene promoters that lack estrogen response elements, such as monoamine oxidase-A and serotonin 1A receptor. Estradiol increases tryptophan hydroxylase-2 and serotonin transporter expression and decreases the expres-sion of serotonin 1A receptor and monoamine oxidase A and B through the interaction with its intracellular receptors. The understanding of molecular mechanisms of estradiol regulation on the protein expression that modulates serotonin neuro-transmission will be helpful for the development of new and more effective treatment for women with depression.