Non-soya legume-based therapeutic lifestyle change diet reduces inflammatory status in diabetic patients: a randomised cross-over clinical trial
Non-soya legume-based therapeutic lifestyle change diet reduces inflammatory status in diabetic patients: a randomised cross-over clinical trial
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DOI：
10.1017/s0007114515001725
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发表时间：
2015-07-28
影响因子：
3.6
通讯作者：
Azizi, Fereidoun
中科院分区：
文献类型：
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作者：
Hosseinpour-Niazi, Somayeh;Mirmiran, Parvin;Azizi, Fereidoun
本随机交叉临床试验研究了两种干预饮食（非大豆豆类为基础的治疗性生活方式改变（TLC）饮食与等能无豆类TLC饮食）对2型糖尿病患者炎症生物标志物的影响。一组31名参与者（24名女性和7名男性;体重74.5（SD 7.0）kg;年龄58.1（SD 6.0）岁）被随机分配到以下两种干预饮食之一，为期8周：无豆类TLC饮食或非大豆豆类TLC饮食。后一种饮食与无豆类TLC饮食相同，除了两份红肉被不同类型的煮熟的非大豆豆类（如扁豆、鹰嘴豆、豌豆和豆类）取代，每周3天。干预期之后是4周的洗脱期，之后各组进行8周的交替治疗。在基线和干预期后测量炎症标志物的浓度。与不含豆类的TLC饮食相比，不含大豆豆类的TLC饮食显著降低了超重糖尿病患者的高敏C反应蛋白、IL-6和TNF-α。在等能TLC饮食中用非大豆豆类代替两份红肉，每周3天，可降低超重糖尿病患者的炎症标志物血浆浓度，与体重变化无关。
The present randomised cross-over clinical trial investigated the effects of two intervention diets (non-soya legume-based therapeutic lifestyle change (TLC) diet v. isoenergetic legume-free TLC diet) on inflammatory biomarkers among type 2 diabetic patients. A group of thirty-one participants (twenty-four women and seven men; weight 74.5 (SD 7.0) kg; age 58.1 (SD 6.0) years) were randomly assigned to one of the two following intervention diets for 8 weeks: legume-free TLC diet or non-soya legume-based TLC diet. The latter diet was the same as the legume-free TLC diet, except that two servings of red meat were replaced with different types of cooked non-soya legumes such as lentils, chickpeas, peas and beans over a period of 3 d per week. The intervention period was followed by a washout period of 4 weeks, after which the groups followed the alternate treatment for 8 weeks. Concentrations of inflammatory markers were measured at baseline and after the intervention periods. Compared with the legume-free TLC diet, the non-soya legume-based TLC diet significantly decreased high-sensitivity C-reactive protein, IL-6 and TNF-alpha in overweight diabetic patients. The replacement of two servings of red meat by non-soya legumes in the isoenergetic TLC diet for a period of 3d per week reduced the plasma concentrations of inflammatory markers among overweight diabetic patients, independent of weight change.