Development and evolution of inner ear sensory epithelia and their innervation
Development and evolution of inner ear sensory epithelia and their innervation
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DOI：
10.1002/neu.10098
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发表时间：
2002-11-05
期刊：
影响因子：
--
通讯作者：
Reichardt, LF
中科院分区：
文献类型：
--
作者：
Fritzsch, B;Beisel, KW;Reichardt, LF
本文综述了内耳感觉补片及其神经支配的发展和进化。最近的分子发育数据表明，这些感觉补丁的发展是进化历史的发展重演。这些数据表明，耳朵产生多个，功能多样的感觉上皮细胞划分一个单一的感觉原基。这些上皮细胞将通过基因的重叠表达建立不同的身份，目前已知的基因只有少数。这些区别之一是毛细胞极性的独特模式。一个假设是如何毛细胞极性可能涉及到的六个感觉上皮细胞的逐步隔离。除了作为感觉上皮发育的标志物外，神经营养因子还在向发育中的前庭和耳蜗神经节迁移的分层细胞中表达。这些脱层细胞起源于发育中的感觉上皮或其附近的多个部位，有些还表达神经元标记物，如NeuroD。前体的不同起源提出了一些感觉神经元在耳朵分层之前获得位置信息的可能性。这些分层的感觉神经元的这种身份可以用来将它们的树突导航到它们分层的区域，以及帮助它们导航到它们的中央目标。感觉神经元的导航特性以及获得离散的感觉贴片表型意味着一个更复杂的细分发展中的耳囊比几个可用的基因表达研究表明。(C)2002 Wiley Petiodicals，Inc. J Neurobiol 53：143 - 156，2002.
The development and evolution of the inner ear sensory patches and their innervation is reviewed. Recent molecular developmental data suggest that development of these sensory patches is a developmental recapitulation of the evolutionary history. These data suggest that the ear generates multiple, functionally diverse sensory epithelia by dividing a single sensory primordium. Those epithelia will establish distinct identities through the overlapping expression of genes of which only a few are currently known. One of these distinctions is the unique pattern of hair cell polarity. A hypothesis is presented on how the hair cell polarity may relate to the progressive segregation of the six sensory epithelia. Besides being markers for sensory epithelia development, neurotrophins are also expressed in delaminating cells that migrate toward the developing vestibular and cochlear ganglia. These delaminating cells originate from multiple sites at, or near the developing sensory epithelia and some also express neuronal markers such as NeuroD. The differential origin of precursors raises the possibility that some sensory neurons acquire positional information before they delaminate the ear. Such an identity of these delaminating sensory neurons may be used both to navigate their dendrites to the area they delaminated from, as well as to help them navigate to their central target. The navigational properties of sensory neurons as well as the acquisition of discrete sensory patch phenotypes implies a much more sophisticated subdivision of the developing otocyst than the few available gene expression studies suggest. (C) 2002 Wiley Petiodicals, Inc. J Neurobiol 53: 143-156, 2002.