Streptococcus pneumoniae nasopharyngeal carriage prevalence, serotype distribution, and resistance patterns among children on Lombok Island, Indonesia
Streptococcus pneumoniae nasopharyngeal carriage prevalence, serotype distribution, and resistance patterns among children on Lombok Island, Indonesia
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DOI：
10.1086/319605
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发表时间：
2001-04-01
影响因子：
11.8
通讯作者：
Arjoso, S
中科院分区：
文献类型：
--
作者：
Soewignjo, S;Gessner, BD;Arjoso, S
印度尼西亚是世界第四人口大国，关于儿童肺炎球菌携带率、血清型分布和耐药模式的数据很少。在1997年8月期间，从印度尼西亚龙目岛的484名健康儿童（年龄，0-25个月）中收集了以人口为基础的全岛样本的鼻咽样本。221个肺炎球菌分离株被鉴定，携带率为48%; 66%的分离株为血清群或血清型6、23、15、33或12。所有分离株对青霉素和头孢噻肟敏感。12%的分离株对磺胺甲恶唑或氯霉素不敏感，4%的分离株对这两种药物都不敏感。非敏感微生物最常见的是血清群或血清型6、12和33。龙目岛的肺炎球菌携带率中等，耐药菌株的比例相对较低。目前的7价肺炎球菌结合疫苗中不包括5种最常见血清群和血清型中的至少3种和3种最常见非敏感血清群和血清型中的2种。
Few data exist on childhood pneumococcal carriage prevalence, serotype distribution, and resistance patterns for Indonesia, the world's fourth most populous country. During August 1997, nasopharyngeal samples were collected from a population-based, island-wide sample of 484 healthy children (age, 0-25 months) from Lombok Island, Indonesia. Two hundred twenty-one pneumococcal isolates were identified, for a carriage prevalence of 48%; 66% of isolates were of serogroup or serotype 6, 23, 15, 33, or 12. All isolates were susceptible to penicillin and cefotaxime. Twelve percent of the isolates were nonsusceptible to sulfamethoxazole or chloramphenicol and 4% were nonsusceptible to both of these drugs. Nonsusceptible organisms were most frequently serogroup or serotype 6, 12, and 33. Lombok has a moderate pneumococcal carriage prevalence and a relatively low proportion of resistant isolates. At least 3 of the 5 most common serogroups and serotypes and 2 of the 3 most common nonsusceptible serogroups and serotypes are not included in the current 7-valent pneumococcal conjugate vaccine.