HISTOGENESIS OF LYMPH-NODES IN RAT AND RABBIT
HISTOGENESIS OF LYMPH-NODES IN RAT AND RABBIT
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DOI：
10.1002/ar.1091900204
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
LANGEVOORT, HL
中科院分区：
文献类型：
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作者：
EIKELENBOOM, P;NASSY, JJJ;LANGEVOORT, HL
用光镜观察了大鼠窝淋巴结和兔窝、腹股沟淋巴结的组织发生。特别强调了初始淋巴细胞群在淋巴结端的分布。在妊娠第17天的大鼠，淋巴样细胞沿着静脉壁分布在有限的间叶区。第二天，间质显示一个球状突起，导致淋巴管壁上有一个凹陷，与静脉平行，在这个地方有一个囊状增宽。球状淋巴样突起填满扩张的淋巴管；被膜下窦起源于淋巴管的其余部分。在出生时，淋巴结可分为原始皮质，由基本网状细胞网络中均匀分布的淋巴细胞区域和髓质组成。出生后约3天，在内侧皮质观察到一个含有密集淋巴细胞的卵圆形区域。在接下来的几天里，它向外侧和髓质方向扩张，但不会向外皮质扩张。初级毛囊在出生后18天出现在外皮质。兔的腹股沟和窝淋巴结的发育与大鼠窝淋巴结的组织发生具有相同的特征。淋巴结的形态发生在示意图中总结。
The histogenesis of the popliteal lymph node in the rat and the popliteal and inguinal lymph nodes in the rabbit was examined by light microscopy. Special emphasis was laid on the initial lymphocyte population in the lymph node anlage. In the rat on the 17th day of gestation lymphoid cells populate a limited mesenchymal area along the vein wall. The next day the mesenchyme shows a bulb-shaped outgrowth causing an indentation in the wall of a lymph vessel, running parallel to the vein and having a saccular widening at this place. The bulb-shaped lymphoid outgrowth fills up the widened lymph vessel; the subcapsular sinus originates from the remaining parts of the lymph vessel. At birth the lymph node can be divided into a primitive cortex consisting of an area with evenly scattered lymphocytes among the basic network of reticular cells and a medulla. About 3 days after birth an ovoid area containing a dense concentration of lymphocytes is observed in the inner cortex. In the next days it expands in both lateral and medullary direction but not into the outer cortex. Primary follicles appear in the outer cortex 18 days after birth. The development of the inguinal and popliteal lymph nodes in the rabbit shows the same characteristics as the histogenesis of the popliteal lymph node in the rat. The morphogenesis of the lymph node is summarized in a schematic diagram.