Coronary artery disease and its risk factors in families of young men with angina pectoris and in controls.
Coronary artery disease and its risk factors in families of young men with angina pectoris and in controls.
复制标题
患有心绞痛的年轻男性家庭和对照组的冠状动脉疾病及其危险因素。
DOI：
10.1136/hrt.39.8.875
复制
发表时间：
1977
影响因子：
--
通讯作者：
E. Nikkilä
中科院分区：
文献类型：
--
作者：
A. Rissanen;E. Nikkilä
研究人员对104名56岁以前患有心绞痛的男性的560名亲属和94名对照者的498名亲属进行了冠状动脉疾病的发生及其危险因素的评估，这些人来自两个地理区域，一个是冠状动脉疾病的中度（芬兰南部），另一个是冠状动脉疾病的高发病率（芬兰东部）。65岁前死于冠状动脉疾病的风险，患者父亲（25%）是对照组父亲的5倍。对于患者的兄弟，发生致命或非致命冠状动脉疾病的风险约为60%，是对照组兄弟的5-5倍。患者姐妹的相应风险为30%，是对照组姐妹的25倍。患者母亲的风险没有增加。四分之一的患者家庭表现出明显的冠状动脉疾病聚集性（65岁前有3例或以上冠状动脉疾病）。高脂血症、高血压和糖尿病在无临床冠状动脉疾病的患者家庭的兄弟姐妹中比对照组家庭的兄弟姐妹多2 - 6倍。冠状动脉疾病、高脂血症和高血压在东部对照组家庭中明显比在南部对照组家庭中更常见；这两个地区的患者家属之间的差异不太明显。冠状动脉疾病发病率的增加与这两个地区和东部对照家庭中高脂血症和高血压患病率的增加密切相关。
The occurrence of coronary artery disease and its risk factors were assessed in 560 relatives of 104 men who developed angina pectoris before the age of 56 and in 498 relatives of 94 controls in two geographical areas, one with a moderate (South Finland) and another with a high (East Finland) incidence of coronary artery disease. The risk of dying from coronary artery disease before the age of 65 was 5 times greater for fathers of patients (25%) than for fathers of controls. For brothers of patients, the risk of developing fatal or non-fatal coronary artery disease was about 60 per cent which is 5-5 times greater than that for brothers of controls. The corresponding risk for sisters ofpatients was 30 per cent, which is 2 5 times greater than thatfor sisters of controls. The risk was not increased for mothers ofpatients. One quarter offamilies ofpatients showed distinct clustering of coronary artery disease (3 or more cases of coronary artery disease before the age of 65). Hyper-lipidaemla, hypertension, and diabetes were 2 to 6 times more common among sibs free of clinical coronary artery disease in the families of patients compared with sibs in the families of controls. Coronary artery disease, hyperlipidaemia, and hypertension were significantly more common in control families in the East than in the South; the difference between families of patients in the two areas was less pronounced. Increased rate of coronary artery disease is closely associated with the increased prevalence of hyperlipidaemia and hypertension in families ofpatients in both areas and in control families in the East.