Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.
Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.
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在撒哈拉以南非洲地区发现了三个新的 DP 等位基因：DPB1*7401、DPA1*02013 和 DPA1*0302。
DOI：
10.1111/j.1399-0039.1998.tb03009.x
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Begovich,AB
中科院分区：
文献类型：
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作者：
Steiner,LL;Cavalli,A;Zimmerman,PA;Boatin,BA;Titanji,VP;Bradley,JE;Lucius,R;Nutman,TB;Begovich,AB
对撒哈拉以南非洲的400多名个体进行的人类白细胞抗原-DP基因分型发现了三个新的DP等位基因：DPB1*7401、DPA1*02013和DPA1*0302。DNA测序证实，在一个个体中发现的DPB1*7401是先前在DPB1的六个可变区中描述的序列基序的新组合。在一个个体中发现的DPA1*02013与DPA1*02012相同，只是有两个沉默的替换，即密码子37的T到C的转换和密码子38的A到G的转换。在7个个体中鉴定的DPA1*0302与DPA1*0301相同，只是在密码子66的第二个位置有C到T的转换。这些新等位基因的鉴定使已报道的DPB1等位基因总数达到77个，DPA1等位基因总数达到11个。
HLA‐DP genotyping of over 400 individuals from sub‐Saharan Africa identified three new DP alleles: DPB1*7401, DPAl*02013, and DPAl*0302. DNA sequencing confirmed that DPB1*7401, found in one individual, is a novel combination of previously described sequence motifs in the six variable regions of DPB1. DPA1*02013, found in one individual, is identical to DPAl*02012 except for two silent substitutions, a T to C transition in codon 37, and an A to G transition in codon 38. DPAl*0302, identified in seven individuals, is identical to DPAl*0301 except for a C to T transition at the second position of codon 66. The identification of these novel alleles brings the total number of reported DPB1 alleles to 77 and DPA1 alleles to 11.