Vascular basis for neural tube defects: a hypothesis.
Vascular basis for neural tube defects: a hypothesis.
复制标题
神经管缺陷的血管基础：一个假设。
DOI：
10.1542/peds.80.1.102
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发表时间：
1987
期刊：
影响因子：
8
通讯作者：
Mary C. Phelan
中科院分区：
文献类型：
--
作者：
R. Stevenson;JoAnn C. Kelly;A. Aylsworth;Mary C. Phelan
A hypothesis is set forth that neural tube defects are produced by inadequate nutrient supply to the rapidly growing neural folds. According to this hypothesis, a delay in establishing blood flow or an aberration of blood supply to neural tissue may interfere with nutrition and prevent neural tube closure. The hypothesis was tested by examining the vasculature of fetuses with spinal neural tube defects. In each case, the arterial supply to the region of the neural tube defect was disturbed. Because development of arterial supply to the neural folds predates neural tube closure, these vascular abnormalities are considered to be primary malformations that lead to neural tube defects rather than secondary morphologic disturbances resulting from neural tube defects.
