Early childhood malnutrition predicts depressive symptoms at ages 11-17
Early childhood malnutrition predicts depressive symptoms at ages 11-17
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DOI：
10.1111/j.1469-7610.2010.02208.x
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发表时间：
2010-07-01
影响因子：
7.6
通讯作者：
Harrison, R.
中科院分区：
文献类型：
--
作者：
Galler, J. R.;Bryce, C. P.;Harrison, R.
背景：我们检查了有婴儿营养不良史的巴巴多斯青年和健康对照组中抑郁症状的患病率，以及母亲抑郁介导/调节营养不良影响的程度。方法：使用包含 20 项的量表对抑郁症状进行评估，这些青少年在出生第一年和以后经历过蛋白质-能量营养不良（消瘦或恶性营养不良）发作（11-17 岁）。没有营养不良史的健康年轻人作为对照组。他们的母亲在孩子 5-17 岁时，每隔 2-5 年，在同一测试中完成三次相同的调查问卷。结果：相对于健康对照儿童，先前营养不良的青少年抑郁症状的患病率较高 (p < .001)。当对青少年抑郁评分进行纵向多元回归分析并调整母亲抑郁症状的影响时，由于幼儿期营养不良史而产生的显着影响仍然存在，并且在未经调整的分析中并未明显减弱。我们还发现母亲抑郁症状对青少年抑郁症状有显着的独立影响。结论：幼儿期营养不良独立地导致了在生命第一年经历过严重营养不良的青少年的抑郁症状。这种关系不受母亲抑郁症影响的调节或调节。后期容易患抑郁症是否是生命早期营养不良和相关状况的直接影响，还是由营养不良的更近端神经行为影响介导，仍有待确定。
Background:We examined the prevalence of depressive symptoms in Barbadian youth with histories of infantile malnutrition and in a healthy comparison group and the extent to which the effect of malnutrition was mediated/moderated by maternal depression.Methods:Depressive symptoms were assessed using a 20-item scale administered to youths (11-17 years of age) who had experienced an episode of protein-energy malnutrition (marasmus or kwashiorkor) during the first year of life and in a comparison group of healthy youths without a history of malnutrition. Their mothers completed the same questionnaire on the same test on three occasions when their children were 5-17 years of age at 2-5-year intervals.Results:The prevalence of depressive symptoms was elevated among previously malnourished youth relative to healthy comparison children (p < .001). When youth depression scores were subjected to a longitudinal multiple regression analysis, adjusting for the effect of maternal depressive symptoms, significant effects due to the history of early childhood malnutrition remained and were not discernibly attenuated from an unadjusted analysis. We also found significant independent effects of maternal depressive symptoms on youth depressive symptoms.Conclusion:Early childhood malnutrition contributed independently to depressive symptoms in youths who experienced a significant episode of malnutrition in the first year of life. This relationship was not mediated or moderated by the effects of maternal depression. Whether the later vulnerability to depression is a direct effect of the episode of malnutrition and related conditions early in life or whether it is mediated by the more proximal neurobehavioral effects of the malnutrition remains to be determined.