Metabolic Control of Cardiomyocyte Cell Cycle.
Metabolic Control of Cardiomyocyte Cell Cycle.
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心肌细胞周期的代谢控制。
DOI：
10.14797/mdcvj.1309
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发表时间：
2023
影响因子：
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通讯作者：
中科院分区：
文献类型：
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作者：
目前用于心力衰竭的疗法旨在预防MI损伤后发生的有害重塑，但目前没有可用于替代损失的心肌细胞的疗法。目前正在研究的几种生物能够通过现有心肌细胞的增殖再生心肌。在这篇综述中，我们总结了哺乳动物心脏的主要代谢途径，以及如何通过遗传和药理学方法调节这些代谢途径影响心肌细胞增殖和心脏再生。
Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.