ANATOMICAL-FUNCTIONAL CORRELATION USING AN ADJUSTABLE MRI-BASED REGION OF INTEREST ATLAS WITH POSITRON EMISSION TOMOGRAPHY
ANATOMICAL-FUNCTIONAL CORRELATION USING AN ADJUSTABLE MRI-BASED REGION OF INTEREST ATLAS WITH POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1038/jcbfm.1988.92
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发表时间：
1988-08-01
影响因子：
6.3
通讯作者：
HAKIM, A
中科院分区：
文献类型：
--
作者：
EVANS, AC;BEIL, C;HAKIM, A
描述了一种用于以快速方式组合来自磁共振成像（MRI）或计算机断层摄影（CT）的解剖信息和来自正电子发射断层摄影（PET）的功能信息的过程。MRI数据与基于解剖学的感兴趣区域的定义、存储和调用程序相结合。标准感兴趣区域的图谱（定义为一组18个平行平面，间隔为6 mm）为每个患者切片提供了初始感兴趣区域模板。对比例、方向和位置年龄进行全局调整，以获得初始匹配。然后可以根据需要移动、删除或重绘感兴趣的各个区域。存储感兴趣区域模板的能力确保了长期分析的再现性，并引入了分析技术的标准化。在25个脑结构中，5个神经解剖学训练的观察者的脑葡萄糖利用率（CMRGlc）测量值的平均变异系数从手动感兴趣区域定义的8.1%降低到使用MRI模板方法的4.0%。占位性病变（如肿瘤或梗死）的模板分析用来自卒中研究的PET数据进行了说明，强调了多功能研究的快速，可重复分析的设施。亨廷顿氏病中CMRGlc降低的结构完整尾状核的MRI-PET匹配强调了量化小结构所需的解剖定位的准确性。
A procedure is described for combining anatomical information from magnetic resonance imaging (MRI) or computerized tomography (CT) and functional information from positron emission tomography (PET) in a rapid fashion. MRI data are combined with a procedure for the definition, storage, and recall of anatomically based regions of interest. An atlas of standard regions of interest, defined for a set of 18 parallel planes spaced at 6-mm intervals, provides an initial region of interest template for each patient slice. Global adjustments to scale, orientation, and position age applied to obtain an initial match. Individual regions of interest may then be moved, deleted, or redrawn as needed. The ability to store region of interest templates ensures reproducibility of analysis over long periods and introduces a standardization of analysis technique. In 25 brain structures, the mean coefficient of variation in cerebral glucose utilization rate (CMRGlc) measurements among five neuroanatomically trained observers was reduced from 8.1% for manual region of interest definition to 4.0% using the template approach with MRI. Template analysis for space-occupying lesions such as tumors or infarcts is illustrated with PET data from a stroke study, emphasizing the facility for rapid, reproducible analysis of multifunctional studies. MRI-PET matching for a structurally intact caudate nucleus having reduced CMRGlc in Huntington''s disease emphasizes the accuracy of anatomical localization required to quantify small structures.