Conjoint Analysis of User Acceptability of Sustained Long-Acting Pre-Exposure Prophylaxis for HIV
Conjoint Analysis of User Acceptability of Sustained Long-Acting Pre-Exposure Prophylaxis for HIV
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DOI：
10.1089/aid.2021.0075
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发表时间：
2021-12-28
影响因子：
1.5
通讯作者：
Hope, Thomas J.
中科院分区：
文献类型：
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作者：
Schieffer, Robert J.;Bryndza Tfaily, Ewa;Hope, Thomas J.
艾滋病毒暴露前预防(PrEP)的长效提供方式，如皮下植入，正在开发中。为了促进最终用户的接受和持续使用，了解潜在消费者和医生处方医生对不同植入物特征的偏好、兴趣和相对重要性至关重要。这些关键属性的有序识别允许植入物开发人员将这些反馈纳入产品设计，这在理论上提高了设备的可接受性、可行性和用户体验。在这项研究中，75名开PrEP处方的医生和143名有艾滋病毒风险的男男性行为者(MSM)完成了基于网络的调查，分别直接比较了8到9种不同植入物特征的重要性。联合分析确定了这些特征相对于彼此的重要性。研究中提出的植入物很受欢迎，大多数医生和MSM表示他们可能会推荐或使用它们。该植入物被认为是独特的、可靠的、方便的，以及能够提供更好的依从性。在医生和MSM中采用植入物最关键的因素是(1)在植入物治疗过程中感染艾滋病毒的机会，(2)植入物的保护长度和大小，以及(3)与目前的PrEP口服药丸治疗相比的副作用优势。关于植入物的一些担忧包括副作用和产品的安全性(在MSM中)，以及植入物的成本或保险覆盖水平(医生和MSM)。植入手术本身也存在一些阻力。
Long-acting delivery modalities of HIV pre-exposure prophylaxis (PrEP), such as subdermal implants, are in development. To facilitate end-user uptake and sustained use, it is critical to understand potential consumers' and physician prescribers' preferences about, interest in, and relative importance of different implant features. The ordered identification of these key attributes allows implant developers to incorporate this feedback into product design, which theoretically improves acceptability, feasibility, and user experience with the device. In this study, n = 75 PrEP-prescribing physicians and n = 143 men having sex with men (MSM) at risk for HIV completed web-based surveys that directly compared the importance of eight to nine different implant features, respectively. Conjoint analysis determined the importance of these features, relative to each other. Implants presented in the study were well received, with a majority of physicians and MSM indicating that they were likely to recommend or use them. The implant was perceived as unique, reliable, and convenient, as well as able to deliver better compliance. The attributes most critical to the adoption of the implant among physicians and MSM were (1) the chance of becoming infected with HIV while on implant treatment, (2) the length of protection and size of the implant, and (3) the side effect advantages over current PrEP oral pill treatment. Some concerns about the implant included side effects and the product's safety (among MSM) and the cost or insurance coverage level for the implant (both physicians and MSM). There was also some resistance to the implantation procedure itself.