INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY LITHIUM-CHLORIDE - SPECIFIC EFFECT OR NONSPECIFIC STRESS
INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY LITHIUM-CHLORIDE - SPECIFIC EFFECT OR NONSPECIFIC STRESS
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DOI：
10.1016/0162-3109(91)90045-z
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发表时间：
1991-11-01
期刊：
影响因子：
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通讯作者：
SALTZMAN, A
中科院分区：
文献类型：
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作者：
LEVINE, S;SALTZMAN, A
腹腔注射氯化锂可抑制大鼠实验性过敏性脑脊髓炎（EAE）的发展。 抑制程度与免疫刺激的强度成反比，这取决于佐剂的选择。 需要高剂量的锂、腹膜内途径和间歇性给药方案才能抑制 EAE。 这表明免疫抑制是一种毒性作用，至少部分是通过下丘脑-垂体-肾上腺皮质轴介导的。 这一假设得到了证据的支持，即锂治疗方案，尤其是间歇方案，在完整大鼠中引起肾上腺皮质激活和胸腺溶解，并且对肾上腺切除的大鼠是致命的。 锂还可以抑制过继免疫产生的 EAE，从而影响免疫反应的传出臂。 单剂量的锂对这种形式的 EAE 有效，甚至对肾上腺切除的大鼠也是如此。 因此，锂通过特异性免疫抑制和非特异性肾上腺皮质依赖性机制影响 EAE。
Intraperitoneal injections of lithium chloride inhibited development of experimental allergic encephalomyelitis (EAE) in rats. The degree of inhibition was inversely related to the intensity of the immunologic stimulation, which depended on the choice of adjuvant. High dosage of lithium, the intraperitoneal route, and an intermittent schedule of administration were required to achieve suppression of EAE. This suggested that the immunosuppression was a toxic effect, mediated, at least in part, through the hypothalamic-pituitary-adrenal cortex axis. This hypothesis was supported by evidence that the lithium treatment schedule, especially the intermittent schedule, had caused adrenal cortical activation with thymolysis in intact rats and that it was lethal to adrenalectomized rats. Lithium also inhibited EAE produced by adoptive immunization, thus implicating the efferent arm of the immune response. A single dose of lithium was effective in this form of EAE, even in adrenalectomized rats. Therefore lithium affects EAE by both specific immunosuppressive and nonspecific adrenocortical-dependent mechanisms.