Oxidation and Acid Milieu-Disintegratable Nanovectors with Rapid Cell-Penetrating Helical Polymer Chains for Programmed Drug Release and Synergistic Chemo-Photothermal Therapy
Oxidation and Acid Milieu-Disintegratable Nanovectors with Rapid Cell-Penetrating Helical Polymer Chains for Programmed Drug Release and Synergistic Chemo-Photothermal Therapy
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具有快速细胞穿透螺旋聚合物链的氧化和酸环境可崩解纳米载体，用于程序药物释放和协同化疗光热疗法
DOI：
10.1021/acs.macromol.6b02063
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发表时间：
2016-10-25
期刊：
影响因子：
5.5
通讯作者：
Wu, Zong-Quan
中科院分区：
文献类型：
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作者：
Chen, Yu;Zhang, Zhi-Huang;Wu, Zong-Quan
与小分子相比，聚合物组装体的特点是易于制备，载药量高，循环时间长，使它们非常有希望用于癌症诊断和治疗。然而，传统的具有无规卷曲表面的纳米载体的治疗效果总是被证明是不太有效的，因为存在几个系统和细胞屏障或纳米载体本身的低组织渗透。为了填补这一空白，我们报道了一类新的氧化和pH双重响应的两亲性三嵌段共聚物：聚（1-乳酸）（-IR 780）-b-疏水性聚（苯基异腈）-b-亲水性聚（苯基异腈）（PLLA（-IR 780）-HBPPI-HPPPI）。在中性水溶液中，该共聚物可形成直径约为84 nm的洋葱状球形胶束，胶束由聚乙二醇化的单左旋螺旋PPI冠构成，赋予其快速的细胞膜渗透性和内化（10-20 min），具有类似于细胞穿透肽（CPPs）的作用。莫
Polymeric assemblies are distinguished by ease of preparation, high drug-loading content, and long circulation time compared to small molecular, making them quite promising for cancerous diagnosis and therapy. However, the therapeutic efficacy of traditional nanocarriers with random coil surface is always proved to be less effective because of the existence of several systemic and cellular barriers or the low tissue penetration from nanocarrier itself. To fill this gap, we report a new class of oxidation and pH dual-responsive amphiphilic triblock copolymer: poly(l-lactic acid)(-IR780)-b-hydrophobic poly(phenyl isocyanide)-b-hydrophilic poly(phenyl isocyanide) (PLLA(-IR780)-HBPPI-HPPPI). In neutral aqueous solution, the copolymers could form onion-like spherical micelles with diameter of ∼84 nm and consisting of PEGylated single left-handed helical PPI corona, endowing them rapid cell membrane permeability and internalization (10–20 min) that had an analogous effect of cell penetrating peptides (CPPs). Mo...