Cell based therapies for ischemic stroke: from basic science to bedside.
Cell based therapies for ischemic stroke: from basic science to bedside.
复制标题
缺血性中风的细胞疗法：从基础科学到临床。
DOI：
10.1016/j.pneurobio.2013.11.007
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发表时间：
2014-04
影响因子：
6.7
通讯作者：
Chen, Jieli
中科院分区：
文献类型：
--
作者：
Liu, Xinfeng;Ye, Ruidong;Yan, Tao;Yu, Shan Ping;Wei, Ling;Xu, Gelin;Fan, Xinying;Jiang, Yongjun;Stetler, R. Anne;Liu, George;Chen, Jieli
细胞疗法正在成为中风后恢复神经功能的可行疗法。不同来源的干细胞/祖细胞治疗中风的可行性和有效性已被探索。移植的细胞不仅有可能取代丢失的神经回路，而且还会产生生长和营养因子，或刺激宿主脑细胞释放这些因子，从而增强内源性脑修复过程。虽然干细胞/祖细胞在缺血性脑卒中的实验研究和初步临床试点研究中显示出了很好的作用，但细胞治疗在人类中仍处于早期阶段。许多关键问题需要解决，包括治疗时间窗口，细胞类型选择，传递途径和体内监测其迁移模式。本文综述了各种供体细胞类型的临床前证据和临床经验，它们的修复机制，传递途径，成像策略，未来的前景和挑战，将细胞疗法转化为临床应用的神经修复方案。
Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications.
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慢性中风中的自体间充质干细胞。
影响因子：
1.9
作者：
Bhasin A;Srivastava MV;Kumaran SS;Mohanty S;Bhatia R;Bose S;Gaikwad S;Garg A;Airan B
通讯作者：
Airan B
影响因子：
4.5
作者：
Alcalá-Barraza SR;Lee MS;Hanson LR;McDonald AA;Frey WH 2nd;McLoon LK
通讯作者：
McLoon LK
DOI：
10.1523/jneurosci.0698-11.2011
发表时间：
2011-06-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akpan N;Serrano-Saiz E;Zacharia BE;Otten ML;Ducruet AF;Snipas SJ;Liu W;Velloza J;Cohen G;Sosunov SA;Frey WH 2nd;Salvesen GS;Connolly ES Jr;Troy CM
通讯作者：
Troy CM
影响因子：
11.2
作者：
Bang, OY;Lee, JS;Lee, G
通讯作者：
Lee, G
影响因子：
5.3
作者：
Barbosa da Fonseca, Lea Mirian;Gutfilen, Bianca;de Freitas, Gabriel R.
通讯作者：
de Freitas, Gabriel R.