Association of polypharmacy with fall risk among geriatric outpatients
Association of polypharmacy with fall risk among geriatric outpatients
复制标题
DOI：
10.1111/j.1447-0594.2011.00703.x
复制
发表时间：
2011-10-01
影响因子：
3.3
通讯作者：
Ouchi, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Kojima, Taro;Akishita, Masahiro;Ouchi, Yasuyoshi
目的：调查跌倒风险与合并症和药物治疗的关系，在老年门诊病人的横断面design.Methods：共262例门诊病人（84名男性和178名女性，平均年龄76.2 +/- 6.8岁）进行了评估。从每例患者获得体格检查、临床病史和药物概况。以过去一年内的福尔斯跌倒史、22项跌倒危险指数、13点跌倒简易筛查试验和单腿站立试验的时间间隔作为跌倒危险的标志。在单变量分析中，年龄较大、女性、高血压、骨质疏松症、卒中史、合并症数量、抗高血压药、阿司匹林、双磷酸盐类药物的使用，催眠药和处方药的数量与四个指数中的任何一个显著相关。在多元回归分析中，药物数量与所有四个指标相关，独立于单变量分析中的其他相关因素。跌倒风险指数的药物数量的关联是stepped.Conclusion：在老年门诊患者，多药，而不是合并症的数量与跌倒风险。需要前瞻性和干预性研究来阐明多种药物、合并症和跌倒风险之间的因果关系。Geriatr Gerontol Int 2011; 11：438-444.
Aim: To investigate the association of fall risk with comorbidities and medications in geriatric outpatients in a cross-sectional design.Methods: A total of 262 outpatients (84 men and 178 women, mean age 76.2 +/- 6.8 years) were evaluated. Physical examination, clinical histories and medication profile were obtained from each patient. History of falls in the past year, 22-item fall risk index, 13-point simple screening test for fall, and time interval of one-leg standing test were examined as markers of fall risk.Results: On univariate analysis, older age, female sex, hypertension, osteoporosis, history of stroke, number of comorbidities, use of antihypertensives, aspirin, bisphosphonates, hypnotics and number of prescribed drugs were significantly associated with either of four indices. On multiple regression analysis, the number of drugs was associated with all of the four indices, independent of other factors associated in the univariate analysis. The association of number of drugs with fall risk indices was stepwise.Conclusion: In geriatric outpatients, polypharmacy rather than number of comorbidities was associated with fall risk. Prospective and intervention studies are needed to clarify the causal relationship between polypharmacy, comorbidities and fall risk. Geriatr Gerontol Int 2011; 11: 438-444.