Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
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DOI：
10.1093/brain/awf128
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发表时间：
2002-06-01
期刊：
影响因子：
14.5
通讯作者：
Dostrovsky, JO
中科院分区：
文献类型：
--
作者：
Levy, R;Ashby, P;Dostrovsky, JO
帕金森病患者的局部场电位和丘脑底核（STN）中的神经元对显示出15-30 Hz的高频振荡（HFO）。本研究探讨了这些HFO是如何调制的自愿运动和多巴胺能药物。我们检查了15例接受植入双侧脑深部刺激电极的患者，使用微电极记录的神经元对（8例）和宏电极记录的局部场电位从小脑（14例）。在手术室中有震颤的5名患者的37对神经元中，有28对神经元之间观察到了同步的HFO，而在没有震颤的3名患者的45对神经元中没有观察到同步的HFO。在三个nontremulous患者中的两个，HFOs在局部场电位的频谱检测到，但弱于震颤的患者。主动运动抑制同步HFO在三个五对神经元，独立的放电率的变化。在14名患者中的9名中观察到的局部场电位中的HFO随着8名受试患者中的6名中的自愿运动而减少。多巴胺能药物降低了HFO的发生率同步的神经元对，减少了HFO同步性在一对震颤细胞同时减少放电率和肢体震颤，并减少HFO的局部场电位在小脑延髓。这些结果表明，自发运动和外源性多巴胺能药物降低了HFO的同步化。提出了基底神经节神经元振荡同步化的一种机制。这表明，发射的β神经元可以同步的15-30赫兹皮层β振荡活动，特别是当多巴胺缺乏导致在一个较高的背景放电率的β神经元，这种同步有助于帕金森病的病理生理。
Local field potentials and pairs of neurones in the subthalamic nucleus (STN) of patients with Parkinson's disease show high-frequency oscillations (HFOs) at 15-30 Hz. This study explores how these HFOs are modulated by voluntary movements and by dopaminergic medication. We examined 15 patients undergoing implantation of bilateral deep brain stimulating electrodes using microelectrode recordings of pairs of STN neurones (eight patients) and macroelectrode recordings of local field potentials from the STN (14 patients). Synchronized HFOs between STN neurones were observed in 28 out of 37 pairs in five patients who had tremor in the operating room and none of 45 pairs in three patients who did not. In two of the three nontremulous patients, HFOs in the frequency spectra of local field potentials were detected but were weaker than in those patients with tremor. Active movement suppressed synchronized HFOs in three out of five pairs of neurones, independent of changes in firing rate. HFOs observed in the local field potentials in nine out of 14 patients were reduced with voluntary movement in six of the eight patients tested. Dopaminergic medication decreased the incidence of synchronized HFOs in STN neurone pairs, reduced HFO synchrony in a pair of tremor cells concurrent with a reduction in firing rate and limb tremor, and decreased HFOs of local field potentials in the STN. These results demonstrate that HFO synchronization in the STN is reduced by voluntary movements and by exogenous dopaminergic medication. A mechanism for neuronal oscillatory synchronization in basal ganglia is proposed. It is suggested that the firing of STN neurones can be synchronized by 15-30 Hz cortical beta oscillatory activity, particularly when dopamine deficiency results in a higher background firing rate of STN neurones, and that this synchronization contributes to parkinsonian pathophysiology.