Separation of cyclodextrins using cyclodextrin bonded phases

Separation of cyclodextrins using cyclodextrin bonded phases
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使用环糊精键合相分离环糊精

DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. Armstrong
D. Armstrong
中科院分区：
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文献类型：
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作者：
H. Jin;A. Stalcup;D. Armstrong

文献摘要

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摘要采用α和β两种环糊精键合相分离α-、β-和γ-环糊精。一般来说，β-环糊精相比α-环糊精键合相更能有效地溶解环糊精。乙腈/水混合物作为流动相。考察了流动相组成对保留和分辨率的影响。发现洗脱顺序与大小有关。从整体保留机制的角度对结果进行了讨论。
Abstract Two different cyclodextrin bonded phases (α and β) were used for the separation of α-, β-and γ-cyclodextrins. The β-cyclodextrin phase was found to be, in general, more effective at resolving the cyclodextrins than the α-cyclodextrin bonded phase. Acetonitrile/water mixtures were used as mobile phases. The effect of mobile phase composition on retention and resolution is examined. The elution order was found to be size dependent. The results are discussed in terms of the overall retention mechanism.