QUALITATIVE MAPPING OF CEREBRAL BLOOD-FLOW AND FUNCTIONAL LOCALIZATION WITH ECHO-PLANAR MR-IMAGING AND SIGNAL TARGETING WITH ALTERNATING RADIO-FREQUENCY
QUALITATIVE MAPPING OF CEREBRAL BLOOD-FLOW AND FUNCTIONAL LOCALIZATION WITH ECHO-PLANAR MR-IMAGING AND SIGNAL TARGETING WITH ALTERNATING RADIO-FREQUENCY
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DOI：
10.1148/radiology.192.2.8029425
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发表时间：
1994-08-01
期刊：
影响因子：
19.7
通讯作者：
WARACH, S
中科院分区：
文献类型：
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作者：
EDELMAN, RR;SIEWERT, B;WARACH, S
目的：利用交替射频回波平面成像和信号定位技术（EPISTAR）建立脑血流量（CBF）定性图。材料和方法：EPISTAR技术在猪高碳酸血症模型中进行，然后在26名志愿者中通过使用各种皮层激活范式进行测试。使用和不使用射频反转脉冲应用于流入动脉旋转获得回声平面图像。然后，通过将不使用射频脉冲获得的图像与使用射频脉冲获得的图像相减，创建了脑血流的定性图。结果：随着流入时间的延长，标记血管的远端部分逐渐增加，直到在大约1秒或更长时间的流入时间内看到皮质增强。从休息到感觉运动激活，信号强度增加了13%到193%。脑血流在运动带、初级视觉皮层和眼动运动区域的变化很好地定位于皮层灰质带。结论：EPISTAR技术是一种快速、无创的建立脑血流定性图谱的方法。
PURPOSE: To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique.MATERIALS AND METHODS: The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using various paradigms for cortical activation. Echo-planar images were acquired with and without use of a radio-frequency inversion pulse applied to inflowing arterial spins. A qualitative map of CBF was then created by subtracting the image obtained without the radio-frequency pulse from that obtained with the radio-frequency pulse.RESULTS: Progressively more distal portions of the tagged vessels were seen as the inflow time was lengthened until cortical enhancement was seen for inflow times of approximately 1 second or longer. Signal intensity increases from rest to sensorimotor activation ranged from 13% to 193%. CBF changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon.CONCLUSION: The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of CBF.