Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection.
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DOI：
10.1186/1471-230x-10-92
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发表时间：
2010-08-13
影响因子：
2.4
通讯作者：
Joven J
中科院分区：
文献类型：
--
作者：
Aragonès G;Alonso-Villaverde C;Oliveras-Ferraros C;Beltrán-Debón R;Rull A;Rodríguez-Sanabria F;Camps J;Martín AV;Menéndez JA;Joven J
脂肪酸合成酶（Fatty acid synthase， FASN）是肝脏合成的一种酶，在脂肪生成中起重要作用。本研究旨在探讨血清FASN浓度是否可能在HIV和/或HCV病毒感染与HIV/HCV感染患者中常见的脂质代谢紊乱之间提供直接联系。我们评估了191例连续hiv感染患者在没有或存在HCV合并感染情况下的血清FASN浓度。为了进行比较，纳入了102名未感染的对照组。还比较了HCV合并感染的代谢和炎症表型。hiv感染患者的血清FASN浓度显著高于健康参与者，HCV合并感染患者的血清FASN浓度高于未合并感染的患者。水平也受治疗方案的影响，但受病毒学变量的影响很小。胰岛素浓度是代谢参数中唯一显示与血清FASN浓度显著相关的变量。血清丙氨酸转氨酶（ALT）值与血清FASN浓度显著相关，并提供了关于HCV合并感染存在与否的最佳区分。在多变量分析中，只有ALT、单核细胞趋化蛋白-1 （MCP-1）和抗逆转录病毒治疗方案的存在能显著解释HIV/HCV合并感染患者血清FASN浓度。hiv感染者血清FASN浓度显著升高。在合并HCV感染的患者中，FASN释放到血液循环中进一步增强。后续研究应探索该指标在监测病毒感染对疾病进展和生存的影响方面的有用性。
Fatty acid synthase (FASN) is an enzyme synthesized by the liver and plays an important role in lipogenesis. The present study aimed to investigate whether serum FASN concentration may provide a direct link between HIV and/or HCV viral infections and lipid metabolic disorders commonly observed in HIV/HCV-infected patients. We evaluated serum FASN concentration in 191 consecutive HIV-infected patients in the absence or presence of HCV co-infection. For comparison, 102 uninfected controls were included. Metabolic and inflammatory phenotype was also compared with respect to the presence of HCV co-infection. Serum FASN concentration was significantly higher in HIV-infected patients than in healthy participants and HCV co-infected patients showed higher levels than those without co-infection. Levels were also affected by treatment regimen, but marginally influenced by virological variables. Insulin concentration was the sole variable among metabolic parameters that demonstrated a significant correlation with serum FASN concentrations. Serum alanine aminotransferase (ALT) values correlated significantly with serum FASN concentration and provided the best discrimination with respect to the presence or absence of HCV co-infection. In multivariate analysis, only ALT, monocyte chemoattractant protein-1 (MCP-1) and the presence of antiretroviral treatment regimen significantly contributed to explain serum FASN concentration in HIV/HCV co-infected patients. Serum FASN concentration is significantly increased in HIV-infected individuals. The release of FASN into the circulation is further enhanced in patients who are co-infected with HCV. Subsequent studies should explore the usefulness of this indicator to monitor the effect of viral infections on disease progression and survival.