Plasma inactivation of candida albicans by an atmospheric cold plasma brush composed of hollow fibers
Plasma inactivation of candida albicans by an atmospheric cold plasma brush composed of hollow fibers
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DOI：
10.1109/tps.2012.2183622
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发表时间：
2012-02
影响因子：
1.5
通讯作者：
Ying Song;Dongping Liu;Longfei Ji;Wenchun Wang;Jinhai Niu;Xianhui Zhang
中科院分区：
文献类型：
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作者：
Ying Song;Dongping Liu;Longfei Ji;Wenchun Wang;Jinhai Niu;Xianhui Zhang
在大气压下产生均匀、大面积的冷等离子体仍然是一个挑战。在本文中，我们报告了一种方法来产生一个可靠的和均匀的刷状等离子体羽在大气压下运行。等离子体刷（长110 mm，宽10 mm）主要由排列良好的中空光纤组成。电流-电压测量结果表明，刷状等离子体羽流由脉宽为几微秒的辉光脉冲放电组成。O原子沿着等离子体刷横向位置的均匀分布进一步证明了He/O2类辉光放电的产生。该刷状等离子体羽流用于白色念珠菌细胞的等离子体灭活中的应用。当暴露于O2/He（体积比：5/95）刷状等离子体羽流150 s时，约97%的具有105个孢子的白念珠菌细胞被杀死。分析表明，等离子体激活的物种，如O自由基，可能在杀死耐药白念珠菌细胞中起着至关重要的作用。
It remains a challenge to generate the uniform and large-area cold plasma at atmospheric pressure. In this paper, we report a method to generate a reliable and homogeneous brush-shaped plasma plume running at atmospheric pressure. The plasma brush (110 mm in length and 10 mm in width) is mainly composed of well-aligned and hollow optical fibers. Current-voltage measurements indicate that the brush-shaped plasma plume consists of glowlike pulsed discharge with their pulsewidths of several microseconds. The generation of the He/O2 glowlike discharge is further proved by the uniform distribution of O atoms along the transverse location of the plasma brush. This brush-shaped plasma plume is used for the application in the plasma inactivation of Candida albicans cells. About 97% of Candida albicans cells with a population of 105 spores are killed when exposed to the O2/He (volume ratio: 5/95) brush-shaped plasma plume for 150 s. Analysis indicates that plasma-activated species, such as O radicals, may play a crucial role in killing the resistant Candida albicans cells.