Evidence of epigenetic admixture in the Colombian population.
Evidence of epigenetic admixture in the Colombian population.
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DOI：
10.1093/hmg/ddw407
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发表时间：
2017-02-01
影响因子：
3.5
通讯作者：
Tenesa A
中科院分区：
文献类型：
--
作者：
Rawlik K;Rowlatt A;Sanabria-Salas MC;Hernández-Suárez G;Serrano López ML;Zabaleta J;Tenesa A
在淋巴母细胞系中测得的DNA甲基化(DNaM)已被反复证明在不同的人类群体中是不同的。由于dNaM在控制基因表达方面的作用，这些差异可能会显著地导致种族表型差异。然而，由于之前的研究比较了遗传和环境背景混淆的不同种族群体，它们对种族之间表型差异的相对贡献仍不清楚。利用来自哥伦比亚的132名混血个体的全血和结肠组织中的dNaM分析，我们确定了不同dNaM水平与当地祖先遗传背景相关的位置。我们的结果与群体特异性dNaM是一致的，主要是由顺式基因中群体间的遗传差异驱动的，几乎没有环境贡献，而且跨组织的影响是一致的。这些发现为解释不同种族之间表型差异的可能机制提供了新的见解，并有助于解释结直肠癌发病率的种族差异。
DNA methylation (DNAm) measured in lymphoblastoid cell lines has been repeatedly demonstrated to differ between various human populations. Due to the role that DNAm plays in controlling gene expression, these differences could significantly contribute to ethnic phenotypic differences. However, because previous studies have compared distinct ethnic groups where genetic and environmental context are confounded, their relative contribution to phenotypic differences between ethnicities remains unclear. Using DNAm assayed in whole blood and colorectal tissue of 132 admixed individuals from Colombia, we identified sites where differential DNAm levels were associated with the local ancestral genetic context. Our results are consistent with population specific DNAm being primarily driven by between population genetic differences in cis, with little environmental contribution, and with consistent effects across tissues. The findings offer new insights into a possible mechanism driving phenotypic differences among different ethnic groups, and could help explain ethnic differences in colorectal cancer incidence.