Chronic pulmonary complications of early influenza virus infection in children.
Chronic pulmonary complications of early influenza virus infection in children.
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儿童早期流感病毒感染的慢性肺部并发症。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
N. Huang
中科院分区：
文献类型：
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作者：
L. Laraya;A. Deforest;D. Huff;H. Lischner;N. Huang
3例男性患者在5、24和42月龄时流感病毒感染后出现慢性肺部后遗症。肺活检发现不同程度的间质纤维化、支气管和细支气管糜烂和化生、闭塞性细支气管炎和间质慢性炎性浸润。在一名病人发病后8周，从其肺组织中分离出甲型流感/香港/68（H3 N2）病毒。这是迄今为止报道的感染性病毒在肺组织中持续时间最长的一次。持续的影像学异常包括支气管周围增厚、间质密度、支气管扩张、闭塞性细支气管炎和节段性肺不张。肺功能检查显示阻塞性限制型，支气管扩张后轻度改善，运动后恶化。这些观察结果表明，流感病毒感染在婴幼儿中可能比以前认识到的更严重，并可能导致不明原因的间质性肺炎、肺纤维化、闭塞性细支气管炎和支气管扩张的发病机制。
In 3 male patients, chronic pulmonary sequelae followed influenza virus infection at 5, 24, and 42 months of age. Varying degrees of interstitial fibrosis, bronchial and bronchiolar erosions and metaplasia, obliterative bronchiolitis, and interstitial chronic inflammatory infiltrates were found on lung biopsy. Influenza A/Hong Kong/68 (H3N2) virus was isolated from the lung tissue of one patient 8 weeks after the onset of illness. This is the longest persistence of infectious virus in lung tissue yet reported. Persistent radiographic abnormalities included peribronchial thickening, interstitial densities, bronchiectasis, obliterative bronchiolitis, and segmental atelectasis. Pulmonary function tests showed an obstructive restrictive pattern, with mild improvement after bronchodilation and with deterioration after exercise. These observations suggest that influenza virus infection may be more serious in infants and young children than has been previously recognized and may contribute to the pathogenesis of unexplained interstitial pneumonitis, pulmonary fibrosis, obliterative bronchiolitis, and bronchiectasis.