A case of anaplastic ductal carcinoma of the pancreas with production of granulocyte-colony stimulating factor.
A case of anaplastic ductal carcinoma of the pancreas with production of granulocyte-colony stimulating factor.
复制标题
产生粒细胞集落刺激因子的胰腺未变性导管癌一例。
作者：
N. Gotohda;T. Nakagohri;N. Saitō;M. Ono;M. Sugito;Masaaki Ito;Kazuto Inoue;T. Oda;Shinichirou Takahashi;T. Kinoshitá
我们报告一例46岁男性胰腺间变性导管癌伴粒细胞集落刺激因子产生的病例。他接受了远端胰腺切除、全胃切除Roux-en-Y重建和脾切除。术后恢复顺利，于术后第22天出院。组织学检查显示胰腺间变性导管癌(巨细胞型)。术后3个月CT扫描发现多发肝转移灶，外周血白细胞数升至81800个/微升。血清粒细胞集落刺激因子浓度为155pg/m L(正常5.78~27.5pg/m L)。因此，我们诊断为产生粒细胞集落刺激因子的胰腺癌。胰腺间变性导管癌并产生粒细胞集落刺激因子是非常罕见的。产生粒细胞集落刺激因子的肿瘤是高度恶性的，这位患者在手术后四个月死于肝功能衰竭。
We report a case of anaplastic ductal carcinoma of the pancreas with production of granulocytecolony stimulating factor in a 46-year-old man. He underwent distal pancreatectomy, total gastrectomy with Roux-en-Y reconstruction and splenectomy. He recovered uneventfully postoperatively and was discharged from hospital on the 22nd postoperative day. Histological examination showed anaplastic ductal carcinoma (giant cell type) of the pancreas. However, three months after the operation, multiple liver metastases were demonstrated by CT scan and the peripheral leukocyte count rose to 81,800/microL. Serum granulocyte-colony stimulating factor concentration was 155pg/mL (normal 5.78-27.5 pg/mL). Therefore, we diagnosed granulocyte-colony stimulating factor-producing pancreatic cancer. Anaplastic ductal carcinoma of the pancreas with production of granulocyte-colony stimulating factor is very rare. Tumors with production of granulocyte-colony stimulating factor are highly malignant, and this patient died of hepatic failure four months after the operation.