AN ANALYSIS OF CODON USAGE IN MAMMALS - SELECTION OR MUTATION BIAS
AN ANALYSIS OF CODON USAGE IN MAMMALS - SELECTION OR MUTATION BIAS
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DOI：
10.1007/bf02103136
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发表时间：
1991-11-01
影响因子：
3.9
通讯作者：
EYREWALKER, AC
中科院分区：
文献类型：
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作者：
EYREWALKER, AC
一种新的统计测试已经开发出来，以检测选择沉默的网站。 该测试比较了基因内的密码子使用，因此不需要知道哪些基因处于最大选择下，基因之间的密码子使用存在共同趋势，或者基因具有相同的突变模式。 它还控制可能由相邻碱基引入的突变偏倚。 该测试应用于62个哺乳动物序列，在所有三个物种（人类，大鼠和小鼠）中检测到显着的密码子使用偏好。 然而，这些偏差似乎不是选择的结果，而是密码子中第一个碱基对影响第三个位置的突变模式的结果。
A new statistical test has been developed to detect selection on silent sites. This test compares the codon usage within a gene and thus does not require knowledge of which genes are under the greatest selection, that there exist common trends in codon usage across genes, or that genes have the same mutation pattern. It also controls for mutational biases that might be introduced by the adjacent bases. The test was applied to 62 mammalian sequences, and significant codon usage biases were detected in all three species examined (humans, rats, and mice). However, these biases appear not to be the consequence of selection, but of the first base pair in the codon influencing the mutation pattern at the third position.