Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.
Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.
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DOI：
10.1098/rsos.170807
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发表时间：
2017-08
影响因子：
3.5
通讯作者：
Wilcox RK
中科院分区：
文献类型：
--
作者：
Mengoni M;Kayode O;Sikora SNF;Zapata-Cornelio FY;Gregory DE;Wilcox RK
当前椎间盘损伤的外科治疗的发展可能受益于虚拟环境的人口变化。为了使这些模型可靠，对不同组织的力学特性及其在椎间盘功能力学中的作用的相关描述是非常重要的。这项工作的目的是首先评估在新鲜条件下纤维环的生理环应变（n = 5），以提取纤维外基质的功能行为；然后对纤维环纤维行为进行逆向工程（n = 6）。这是通过执行材料参数的直接和全局控制校准来实现的，考虑到实验设计和硅模型方法的整个过程。直接控制模型是代表受控实验条件的样品特定模型，可以复制并直接比较测量结果。对另外6个标本进行验证，并进行敏感性研究。松弛10 min后的环应变为17±3%，松弛20 ~ 25 min后的环应变为21±4%，两者无显著差异。测定纤维外基质功能模量为1.5±0.7 MPa。纤维相关材料参数变异性较大，方差大于0.28。直接控制的校准和验证提供了信心，模型开发方法可以捕获可测量的变化在测试标本的人口。
The development of current surgical treatments for intervertebral disc damage could benefit from virtual environment accounting for population variations. For such models to be reliable, a relevant description of the mechanical properties of the different tissues and their role in the functional mechanics of the disc is of major importance. The aims of this work were first to assess the physiological hoop strain in the annulus fibrosus in fresh conditions (n = 5) in order to extract a functional behaviour of the extrafibrillar matrix; then to reverse-engineer the annulus fibrosus fibrillar behaviour (n = 6). This was achieved by performing both direct and global controlled calibration of material parameters, accounting for the whole process of experimental design and in silico model methodology. Direct-controlled models are specimen-specific models representing controlled experimental conditions that can be replicated and directly comparing measurements. Validation was performed on another six specimens and a sensitivity study was performed. Hoop strains were measured as 17 ± 3% after 10 min relaxation and 21 ± 4% after 20–25 min relaxation, with no significant difference between the two measurements. The extrafibrillar matrix functional moduli were measured as 1.5 ± 0.7 MPa. Fibre-related material parameters showed large variability, with a variance above 0.28. Direct-controlled calibration and validation provides confidence that the model development methodology can capture the measurable variation within the population of tested specimens.
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影响因子：
2.4
作者：
Adam, Clayton;Rouch, Philippe;Skalli, Wafa
通讯作者：
Skalli, Wafa
影响因子：
3.7
作者：
Casaroli, Gloria;Galbusera, Fabio;Villa, Tomaso
通讯作者：
Villa, Tomaso
影响因子：
2.4
作者：
Michalek, A. J.;Gardner-Morse, M. G.;Iatridis, J. C.
通讯作者：
Iatridis, J. C.
DOI：
10.1016/j.spinee.2012.04.001
发表时间：
2012-05
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Michalek AJ;Iatridis JC
通讯作者：
Iatridis JC
影响因子：
3.8
作者：
Marini, Giacomo;Ferguson, Stephen J.
通讯作者：
Ferguson, Stephen J.