Cells of the Innate and Adaptive Immune Systems in Kaposi's Sarcoma.

Cells of the Innate and Adaptive Immune Systems in Kaposi's Sarcoma.
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DOI:
10.1155/2020/8852221
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发表时间:
2020
影响因子:
4.1
通讯作者:
Munsaka S
Munsaka S
中科院分区:
医学3区
文献类型:
--
作者:
Ngalamika O;Munsaka S

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卡波西肉瘤(KS)是一种血管增生性恶性肿瘤,其相关病原是卡波西肉瘤相关疱疹病毒(KSHV)。KS是全球艾滋病毒感染者中最常见的恶性肿瘤,被认为是艾滋病的恶性肿瘤。不同形式的KS,包括hiv相关KS、医源性(免疫抑制相关)KS和老年男性的经典KS,表明免疫细胞失调是促进kshv感染者KS发展的关键因素之一。因此,我们预计免疫系统的不同细胞类型可能在促进或抑制KS的发展中发挥不同的作用。本文将重点讨论先天性和适应性免疫系统细胞在KSHV感染和KS发病中的作用,包括这些细胞如何在KSHV感染的控制和KS的治疗中发挥作用。
Kaposi's sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi's sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.
DOI: 10.1038/nature04753
发表时间: 2006-05-11
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