Patterns of adherence to antiretrovirals: Why adherence has no simple measure
Patterns of adherence to antiretrovirals: Why adherence has no simple measure
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DOI：
10.1089/108729103322494311
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发表时间：
2003-10-01
影响因子：
4.9
通讯作者：
Fernandez, M
中科院分区：
文献类型：
--
作者：
Hill, Z;Kendall, C;Fernandez, M
本研究的目的是从患者的角度探讨抗逆转录病毒治疗依从性的模式和解释。它包括78个深入采访的病人参加艾滋病毒诊所在新奥尔良，路易斯安那州，谁的联合治疗已被规定。访谈探讨了患者对依从性的定义、对不依从性后果的信念、当前和过去依从性行为的原因以及药物和酒精使用以及社会支持等背景问题。受访者报告了9种不同的坚持模式，他们认为这些模式具有不同的后果和原因。这些模式隐藏了变化，因为受访者可能同时有一个以上的模式，模式并不稳定。虽然依从性测量有黄金标准，例如直接观察治疗，但这些测量最常用于根据受访者是否服用一定比例的药物将其分为依从者或非依从者。这样的分类过于简单，不能反映依从性模式的复杂性。
The goal of this study was to explore patterns and explanations of adherence to antiretroviral therapies from the patient's perspective. It consisted of 78 in-depth interviews with patients attending an HIV clinic in New Orleans, Louisiana, to whom combination therapy had been prescribed. Interviews explored patient's definitions of adherence, beliefs about consequences of nonadherence, reasons for current and past adherence behavior, and contextual issues such as drug and alcohol use and social support. Respondents reported nine distinct patterns of adherence, which they perceived to have different consequences and causes. These patterns hid variations because respondents could have more than one pattern simultaneously and patterns were not stable over time. Although there are gold standards for adherence measurement, such as directly observed therapy, these measurements are most frequently used to classify respondents as adherers or nonadherers based on whether they take a certain percentage of their medication. Such a categorization is simplistic and does not reflect the complexity of adherence patterns.