Vapor inhalation of alcohol in rats.
Vapor inhalation of alcohol in rats.
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DOI：
10.1002/0471142301.ns0929s44
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发表时间：
2008-07
影响因子：
--
通讯作者：
Koob, George F
中科院分区：
文献类型：
--
作者：
Gilpin, Nicholas W;Richardson, Heather N;Cole, Maury;Koob, George F
酒精依赖是一种神经适应性状态，对于理解酒精中毒至关重要，已经利用各种方法诱导动物酒精依赖，其中之一是酒精蒸汽暴露。酒精蒸汽吸入提供了某些优势，其他慢性酒精暴露程序，共同的最终目标是产生酒精依赖的大鼠。慢性酒精蒸汽吸入允许实验者控制酒精暴露的剂量、持续时间和模式。此外，这一程序有助于测试酒精依赖的躯体和动机方面。长期暴露于酒精蒸汽会增加大鼠的饮酒行为、焦虑样行为和奖励缺陷。酒精蒸汽吸入作为实验室方案是灵活的，并且该过程的参数可以调整以适应不同实验的特定目的。本单元描述了研究者使用该程序进行依赖诱导时可用的选项，当不同的选项或多或少合适时，以及每个选项的含义。
Alcohol dependence constitutes a neuroadaptive state critical for understanding alcoholism, and various methods have been utilized to induce alcohol dependence in animals, one of which is alcohol vapor exposure. Alcohol vapor inhalation provides certain advantages over other chronic alcohol exposure procedures that share the ultimate goal of producing alcohol dependence in rats. Chronic alcohol vapor inhalation allows the experimenter to control the dose, duration, and pattern of alcohol exposure. Also, this procedure facilitates testing of somatic and motivational aspects of alcohol dependence. Chronic exposure to alcohol vapor produces increases in alcohol-drinking behavior, increases in anxiety-like behavior, and reward deficits in rats. Alcohol vapor inhalation as a laboratory protocol is flexible, and the parameters of this procedure can be adjusted to accommodate the specific aims of different experiments. This unit describes the options available to investigators using this procedure for dependence induction, when different options are more or less appropriate, and the implications of each.