Increased brain activation during verbal learning in obstructive sleep apnea
Increased brain activation during verbal learning in obstructive sleep apnea
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DOI：
10.1016/j.neuroimage.2006.02.042
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发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Drummond, Sean P. A.
中科院分区：
文献类型：
--
作者：
Ayalon, Liat;Ancoli-Israel, Sonia;Drummond, Sean P. A.
这项研究检查了阻塞性睡眠呼吸暂停 (OSA) 患者对言语学习 (VL) 任务的大脑反应。通过功能磁共振成像 (FMRI) 对 12 名 OSA 患者和 12 名对照组进行了研究。正如假设的那样，两组的 VL 表现相似，但 OSA 患者的几个大脑区域的大脑激活增加。这些区域包括双侧额下回和额中回、扣带回、顶下叶和颞上叶交界处的区域、丘脑和小脑。 OSA 组更好的自由回忆表现与左额下回和左边缘上区的大脑反应增强有关。回忆与左顶下叶内的激活呈负相关。研究结果支持了这样的预测：OSA 患者的完整表现与大脑反应增强相关。 OSA 患者招募额外的大脑区域来参与 VL 表现可能代表一种适应性补偿性招募反应，类似于在完全睡眠剥夺后的年轻人和健康老年人中观察到的情况。这些数据以及 OSA 中唯一的其他 FMRI 研究的数据表明，OSA 患者在应对认知挑战的 BOLD 信号反应方面表现出特征性差异。将未经治疗的 OSA 受试者纳入神经影像学研究可能会通过改变个人和群体水平的激活模式来影响结果。鉴于此，未来的神经影像学研究可能希望意识到这种潜在的混淆。 (c) 2006 Elsevier Inc. 保留所有权利。
This study examined the cerebral response to a verbal learning (VL) task in obstructive sleep apnea (OSA) patients. Twelve OSA patients and 12 controls were studied with functional magnetic resonance imaging (FMRI). As hypothesized, VL performance was similar for both groups, but OSA patients showed increased brain activation in several brain regions. These regions included bilateral inferior frontal and middle frontal gyri, cingulate gyrus, areas at the junction of the inferior parietal and superior temporal lobes, thalamus, and cerebellum. Better free recall performance in the OSA group was related to increased cerebral responses within the left inferior frontal gyrus and left supramarginal area. Recall was negatively related to activation within the left inferior parietal lobe. The findings support the predictions that intact performance in OSA patients is associated with increased cerebral response. Recruitment of additional brain regions to participate in VL performance in OSA patients likely represents an adaptive compensatory recruitment response, similar to that observed in young adults following total sleep deprivation and in healthy older adults. These data, and those of the only other FMRI study in OSA, suggest that individuals with OSA show characteristic differences in the BOLD signal response to cognitive challenges. Including subjects with untreated OSA in neuroimaging studies may potentially influence the results by altering individual and group level activation patterns. Given this, future neuroimaging studies may want to be aware of this potential confound. (c) 2006 Elsevier Inc. All rights reserved.