Impact of Fetal Growth and Preterm Birth on the Retinal Microvasculature in Mid-Adulthood
Impact of Fetal Growth and Preterm Birth on the Retinal Microvasculature in Mid-Adulthood
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DOI：
10.1111/micc.12197
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发表时间：
2015-05-01
期刊：
影响因子：
2.4
通讯作者：
Tapp, Robyn J.
中科院分区：
文献类型：
--
作者：
Hussain, Sultana Monira;Kahonen, Mika;Tapp, Robyn J.
我们假设早产和出生SGA与视网膜微血管结构的变化有关，这些变化在早产儿中更为明显。我们进一步假设，这些微血管的变化将与早期标志物的CVD在成年中期。MethodsThe心血管风险在年轻的芬兰人的研究包括随机选择的儿童从5个芬兰大学城市。对早产儿、足月儿和SGA组以及足月儿和阿加对照组的视网膜微血管结构进行了比较结果在早产儿中，小动脉迂曲度（x10（2））平均值高于对照组，（标准误差），0.06（0.01）与0.04（0.01），p=0.001，小动脉长度（像素）更大644.9校正后，与出生于阿加的参与者相比，小动脉直径（像素）窄19.9（0.4）对20.3（0.3），p=0.034。在出生SGA的参与者中，只有小动脉迂曲度高于0.05（0.01）与0.04（0.01），p=0.074相比，出生阿加.ConclusionThis study demonstrated that being born SGA，特别是早产与视网膜微血管结构的变化。产前和产后环境可能有助于机制。
ObjectiveWe hypothesized that preterm birth and being born SGA would be associated with changes in retinal microvascular architecture and that these changes would be more marked among those born preterm. We further hypothesized that these microvascular changes would correlate with early markers of CVD in mid-adulthood.MethodsThe Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish University cities. Retinal microvascular architecture of participants born preterm, born at term and SGA and a control group born at term and AGA were compared (aged 34-49years).ResultsIn participants born preterm, arteriolar tortuosity (x10(2)) was highermeans (standard error), 0.06 (0.01) versus 0.04 (0.01), p=0.001, arteriolar length (pixels) were greater644.9 (35.9) versus 591.7 (33.5), p=0.007 and arteriolar diameters (pixels) were narrower19.9 (0.4) versus 20.3 (0.3), p=0.034 compared to participants born AGA, after adjustment. In participants born SGA, only arteriolar tortuosity was higher0.05 (0.01) versus 0.04 (0.01), p=0.074 compared to participants born AGA.ConclusionThis study demonstrated that being born SGA and in particular preterm birth are associated with changes in retinal microvascular architecture. The prenatal and immediate postnatal environment may contribute to the mechanisms.