Postprandial regulation of renal hemodynamics: role of pancreatic glucagon.
Postprandial regulation of renal hemodynamics: role of pancreatic glucagon.
复制标题
肾血流动力学的餐后调节：胰高血糖素的作用。
DOI：
10.1152/ajprenal.1985.248.5.f656
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
SmithJr,MJ
中科院分区：
文献类型：
--
作者：
Premen,AJ;Hall,JE;SmithJr,MJ
本研究的目的是确定在餐后状态下，胰高血糖素在调节蛋白质诱导的肾血流量(RBF)和肾小球滤过率(GFR)增加中的定量重要性。6只慢性仪器化清醒犬分别接受4种方案：正常蛋白质控制餐(C)、高蛋白肉粉(M)、生长抑素加肉类输注(S+M)和胰高血糖素输注。C使RBF(12+/-2%)和GFR(14+/-2%)略有增加，但不改变动脉血胰高血糖素水平。M在3小时内使RBF(38+/-4%)、GFR(41+/-5%)和胰高血糖素(从23.3+/-3.6 pg/ml增加到73.3+/-7.1 pg/ml)显著增加。在S+M期间，红细胞压积和肾小球滤过率在2 h内没有增加，而胰高血糖素被抑制了36+/-8%。S停药后1小时内高血糖素升至10 0+/-13.9pg/ml，而RBF和GFR仅分别增加14+/-4和10+/-3%。静脉注射胰高血糖素(3ngX kg-1Xmin-1)血浆胰高血糖素显著升高至131.6+/-27.3pg/ml，但径向血流量和肾小球滤过率无明显变化。这些数据表明，虽然富含蛋白质的肉餐确实会升高动脉血中的胰高血糖素，但这种升高还不足以引起肾脏血流动力学的显著变化。因此，血浆胰高血糖素水平的升高不能解释蛋白质介导的餐后状态下RBF和GFR的增加。
The aim of this study was to ascertain the quantitative importance of glucagon in mediating protein-induced increases in renal blood flow (RBF) and glomerular filtration rate (GFR) during the postprandial state. Six chronically instrumented conscious dogs were each subjected to four protocols: normal protein control meal (C); high protein meat meal (M); somatostatin infusion and meat (S + M); and glucagon infusion. C produced small increases in RBF (12 +/- 2%) and GFR (14 +/- 2%) without changing arterial plasma glucagon. M produced marked increases in RBF (38 +/- 4%), GFR (41 +/- 5%), and glucagon (from 23.3 +/- 3.6 to 73.3 +/- 7.1 pg/ml) over a 3-h period. During S + M, RBF and GFR failed to increase while glucagon was suppressed by 36 +/- 8% over a 2-h period. When S was stopped, glucagon rose to 100 +/- 13.9 pg/ml over the next hour, yet RBF and GFR increased by only 14 +/- 4 and 10 +/- 3%, respectively. Glucagon infusion (3 ng X kg-1 X min-1, i.v.) markedly elevated plasma glucagon to 131.6 +/- 27.3 pg/ml, yet neither RBF nor GFR significantly changed. These data indicate that while a protein-rich meat meal does elevate arterial plasma glucagon, the rise is not great enough to elicit significant changes in renal hemodynamics. Thus, elevated plasma levels of glucagon cannot account for protein-mediated increases in RBF and GFR during the postprandial state.